Research advances in the pyroptosis signaling pathway after intracerebral hemorrhage / 中风与神经疾病杂志

ABSTRACT

@#Pyroptosis is an important mechanism leading to secondary brain injury （SBI） after intracerebral hemorrhage （ICH）， which can be classified into the inflammasome-dependent classical pyroptosis pathway and the caspase-4/5/11-dependent non-classical pyroptosis pathway. GSDMD and GSDME of the gasdermin family are the key effectors of pyroptosis and bind to lipids on cell membrane to induce the formation of membrane pore. Interleukin-1β/-18 is a downstream inflammatory factor that mediates inflammatory injury after pyroptosis. This article reviews the key proteins in the pyroptosis pathway and the mechanism of action of the pyroptosis signaling pathway after ICH.