Metachronous Ovarian Metastases Following Resection of the Primary Gastric Cancer
Journal of Gastric Cancer
; : 31-37, 2011.
Article
en En
| WPRIM
| ID: wpr-103359
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
We performed this study to evaluate the clinical presentation as well as the proper surgical intervention for ovarian metastasis from gastric cancers and these tumors were identified during postoperative follow-up. This will help establish the optimal strategy for improving the survival of patients with this entity. MATERIALS ANDMETHODS:
22 patients (3.2%) with ovarian metastasis were noted when performing a retrospective chart review of (693) females patients who had undergone a resection for gastric cancer between 1981 and 2008. The covariates used for the survival analysis were the patient age at the time of ovarian relapse, the size of the tumor, the initial TNM stage of the gastric cancer, the interval to metastasis and the presence of gross residual disease after treatment for Krukenberg tumor. The cumulative survival curves for the patient groups were calculated with the Kaplan-Meier method and they were compared by means of the Log-Rank test.RESULTS:
The average age of the patients was 48.6 years (range 24 to 78 years) and the average survival time of the 22 patients was 18.8 months (the estimated 3-year survival rate was 15.8%) with a range of 2 to 59 months after the diagnosis of Krukenberg tumor. The survival rate for patients without gross residual disease was longer than that of the patients with gross residual disease (P=0.0003). In contrast, patient age, the size of ovarian tumor, the initial stage of gastric adenocarcinoma, the interval to metastasis and adjuvant chemotherapy were not prognostic indicators for survival after the development of ovarian metastasis.CONCLUSIONS:
Early diagnosis and complete resection are the only possible hope to improve survival. As the 3-year survival rate after resection of Krukenberg tumor is 15.8%, it seems worthwhile to consider performing tumorectomy as the second cytoreduction.Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Recurrencia
/
Neoplasias Gástricas
/
Adenocarcinoma
/
Tasa de Supervivencia
/
Estudios Retrospectivos
/
Estudios de Seguimiento
/
Quimioterapia Adyuvante
/
Tumor de Krukenberg
/
Diagnóstico Precoz
/
Metástasis de la Neoplasia
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Screening_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Journal of Gastric Cancer
Año:
2011
Tipo del documento:
Article