Burnt-out Metastatic Prostate Cancer / 영남의대학술지
Yeungnam University Journal of Medicine
; : 116-119, 2013.
Article
en En
| WPRIM
| ID: wpr-194924
Biblioteca responsable:
WPRO
ABSTRACT
A burnt-out prostate cancer tumor is a very rare clinical entity. The term 'burnt-out' refers to a primary tumor that has spontaneously and nearly completely regressed without treatment. Since metastasis of prostate cancer is usually encountered in the presence of advanced disease, distant metastasis with an undetectable primary tumor is very rare. We report herein a case of a burnt-out prostate cancer tumor that metastasized to the thoracic (T) spine and caused cord compression. A 66-year-old man visited the Emergency Department due to weakness of both legs for the past two days. His blood and urine tests were normal at the time. His spine magnetic resonance imaging (MRI) scans looked like bone metastasis that involved the T-7 vertebral body and a posterior element, and caused spinal cord compression. Other images, including from the brain MRI, neck/chest/abdomino-pelvic computed tomography (CT) scan and 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) and endoscopy, revealed no lesions that suggested malignancy. After total corpectomy T-7 and screw fixation/fusion at T5 to T10, the pathology report revealed a metastatic carcinoma that was strongly positive for prostate-specific antigen (PSA). The serum PSA value was 1.5 ng/mL. The transrectal 12-core prostate biopsy and ultrasonography showed no definitive hypoechoic lesion, but one specimen had slight (only 1%) adenocarcinoma with a Gleason score of 6 (3+3). The final diagnosis was burned-out prostate cancer with an initial normal PSA value. Although metastatic disease with an unknown primary origin was confirmed, a more aggressive approach in seeking the primary origin could provide a more specific treatment strategy and greater clinical benefit to patients.
Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Patología
/
Próstata
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Neoplasias de la Próstata
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Compresión de la Médula Espinal
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Columna Vertebral
/
Biopsia
/
Encéfalo
/
Imagen por Resonancia Magnética
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Adenocarcinoma
/
Ultrasonografía
Tipo de estudio:
Diagnostic_studies
Límite:
Aged
/
Humans
Idioma:
En
Revista:
Yeungnam University Journal of Medicine
Año:
2013
Tipo del documento:
Article