Preoperative single-dose of Zinacef in preventing infection from gynecological surgery

ABSTRACT

The efficacy of pre-operative single dose antimicrobial prophylaxis in preventing infection after gynecological surgery has been demonstrated. In this study 200 patients were randomly enrolled in two groups. Each of the 1st group (n=100) was received 2 g of ampicillin and 160 mg of gentamycin per day, during 7 days of postoperation. Each of the other (n=100) was received 1.5g of cefuroxime (Zinacef) single-dose 15-30 minutes before operation. The two treatments were compared. There was no difference between two groups about the number of white blood cell, the fever and the hospitalization stay. No infectious complication was noted. But in the group receiving Zinacef, the patient felt less painful and the hospitalization stay might be reduced