Expression of tau-related protein in spinal cord of patients with Alzheimer's disease / 中华病理学杂志
Chinese Journal of Pathology
; (12): 161-164, 2011.
Article
en Zh
| WPRIM
| ID: wpr-261837
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of tau-related protein in spinal cord of Chinese patients with Alzheimer's disease.</p><p><b>METHODS</b>Gallays-Braak stain and immunohistochemical study for tau protein (AT8) were carried out in the spinal cord tissue (T2, T8, T10, L2 and S2 segments) of 3 Chinese patients with Alzheimer's disease. Seven age-matched cases without evidence of dementia or neurologic disease were used as controls.</p><p><b>RESULTS</b>Neurofibrillary tangles were identified in the neurons of anterior horn in 2 Alzheimer's disease cases but none was observed in the controls. Tau-positive axons and astroglia were detected in all Alzheimer's disease cases. Tau immunoreactivity in spinal cord of the patients correlated with that in brain tissue.</p><p><b>CONCLUSION</b>The expression of tau-related protein is demonstrated in the spinal cord of Alzheimer's disease patients suggesting that axonal transport defect may play a role in the pathogenesis of Alzheimer's disease.</p>
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Patología
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Fosforilación
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Médula Espinal
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Axones
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Transporte Axonal
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Ovillos Neurofibrilares
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Proteínas tau
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Enfermedad de Alzheimer
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Metabolismo
Límite:
Aged
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Pathology
Año:
2011
Tipo del documento:
Article