Distribution of HBV Genotypes in Patients With Chronic HBV Infection in Korea / 대한간학회지
The Korean Journal of Hepatology
; : 373-380, 2001.
Article
en Ko
| WPRIM
| ID: wpr-34248
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND/AIMS:
Chronic HBV infection is associated with a wide spectrum of clinical manifestations, including asymptomatic carrier state, chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Genotypically, HBV genomes have been classified into seven groups, designated A to G. Several studies have suggested recently that HBV genotypic differences influence the severity of liver disease and clinical outcomes. The distribution of HBV genotypes in Korea and its clinical relevance are poorly understood. We investigated the prevalence of HBV genotypes in Korea and the association between the distinct genotypes and the severity of liver disease.METHODS:
A total of 214 HBV-DNA positive serum samples, were used for the genotyping. All patients were HBV-bDNA positive chronic HBsAg carriers. 199 patients were histologically verified with liver cirrhosis (6), chronic hepatitis (192) and fatty liver (1). The other patients were clinically diagnosed with liver cirrhosis (13) or hepatocellular carcinoma (2). HBV genotype was determined by PCR using type-specific primers.RESULTS:
Genotyping was possible in all patients. Out of 214 patients, 213 (99.5%) were HBV genotype C. Only one (0.5%) was genotype A. The patient with genotype A had minimal hepatitis as diagnosed by liver biopsy.CONCLUSIONS:
These results indicate that almost all chronic HBV infections are genotype C in Korea. HBV genotypic difference therefore does not influence the clinical outcome of HBV infection in Korea. Because genotype C may be associated with more severe liver disease, the predominance of genotype C in Korea may result in more severe outcomes than in other countries where other genotypes are predominant.Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Biopsia
/
Portador Sano
/
Reacción en Cadena de la Polimerasa
/
Epidemiología
/
Prevalencia
/
Genoma
/
Carcinoma Hepatocelular
/
Hígado Graso
/
Genotipo
/
Hepatitis A
Tipo de estudio:
Prevalence_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
Ko
Revista:
The Korean Journal of Hepatology
Año:
2001
Tipo del documento:
Article