Short Insulin Tolerance Test Can Determine the Effects of Thiazolidinediones Treatment in Type 2 Diabetes
Yonsei Medical Journal
; : 901-908, 2008.
Article
en En
| WPRIM
| ID: wpr-34315
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: The short insulin tolerance test is a simple and reliable method of estimating insulin sensitivity. This study was designed to compare the insulin sensitizing effects of thiazolidinediones (TZDs) on the degree of insulin resistance, determined by a short insulin tolerance test (Kitt) in type 2 diabetic patients. PATIENTS AND METHODS: Eighty-three subjects (mean age = 57.87 +/- 10.78) with type 2 diabetes mellitus were enrolled and received daily one dose of rosiglitazone (4mg) or pioglitazone (15mg). The mean follow-up duration was 25.39 +/- 9.66 months. We assessed insulin sensitivity using HOMA-IR and the short insulin tolerance test before and after TZDs treatment. RESULTS: When we compared patients' characteristics before and after TZDs treatment, the mean fasting glucose level was significantly decreased (183.27 +/- 55.04 to 137.35 +/- 36.42mg/dL, p or = 2.5%/min; 3.50 +/- 0.75%/min to 2.75 +/- 1.12%/min, p = 0.002). CONCLUSION: The glucose lowering effects of TZDs by improving insulin resistance could be determined by using Kitt. However, Kitt may be a beneficial tool to determine TZDs' effects only when patients' Kitt values are less than 2.5%/min.
Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Glucemia
/
Resistencia a la Insulina
/
Tiazolidinedionas
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Diabetes Mellitus Tipo 2
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Tolerancia a Medicamentos
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Hipoglucemiantes
/
Insulina
Límite:
Aged
/
Female
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Humans
/
Male
Idioma:
En
Revista:
Yonsei Medical Journal
Año:
2008
Tipo del documento:
Article