Innervation in women with uterine myoma and adenomyosis
Obstetrics & Gynecology Science
; : 150-156, 2015.
Article
en En
| WPRIM
| ID: wpr-36571
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE:
To determine if neurofilament (NF) is expressed in the endometrium and the lesions of myomas and adenomyosis, and to determine their correlation.METHODS:
Histologic sections were prepared from hysterectomies performed on women with adenomyosis (n=21), uterine myoma (n=31), and carcinoma in situ of the uterine cervix. Full-thickness uterine paraffin blocks, which included the endometrium and myometrium histologic sections, were stained immunohistochemically using the antibodies for monoclonal mouse antihuman NF protein.RESULTS:
NF-positive cells were found in the endometrium and myometrium in 11 women with myoma and in 7 with adenomyosis, but not in patients with carcinoma in situ of uterine cervix, although the difference was statistically not significant. There was no significant difference between the existence of NF-positive cells and menstrual pain or phases. The NF-positive nerve fibers were in direct contact with the lesions in nine cases (29.0%) of myoma and in five cases (23.8%) of adenomyosis. It was analyzed if there was a statistical significance between the existence of NF positive cells in the endometrium and the expression of NF-positive cells in the uterine myoma/adenomyosis lesions. When NF-positive cell were detected in the myoma lesions, the incidence of NF-positive nerve cells in the eutopic endometrium was significantly high. When NF-positive cell were detected in the basal layer, the incidence of NF-positive nerve cells in the myoma lesions and adenomyosis lesions was significantly high.CONCLUSION:
We assume that NF-positive cells in the endometrium and the myoma and adenomyosis lesions might play a role in pathogenesis. Therefore, more studies may be needed on the mechanisms of nerve fiber growth in estrogen-dependent diseases.Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Parafina
/
Carcinoma in Situ
/
Cuello del Útero
/
Incidencia
/
Dismenorrea
/
Endometrio
/
Adenomiosis
/
Histerectomía
/
Leiomioma
/
Anticuerpos
Tipo de estudio:
Incidence_studies
/
Prognostic_studies
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Obstetrics & Gynecology Science
Año:
2015
Tipo del documento:
Article