AROS Is a Significant Biomarker for Tumor Aggressiveness in Non-cirrhotic Hepatocellular Carcinoma
Journal of Korean Medical Science
; : 1253-1259, 2015.
Article
en En
| WPRIM
| ID: wpr-53698
Biblioteca responsable:
WPRO
ABSTRACT
Despite a low risk of liver failure and preserved liver function, non-cirrhotic hepatocellular carcinoma (HCC) has a poor prognosis. In the current study, we evaluated an active regulator of SIRT1 (AROS) as a prognostic biomarker in non-cirrhotic HCC. mRNA levels of AROS were measured in tumor and non-tumor tissues obtained from 283 non-cirrhotic HCC patients. AROS expression was exclusively up-regulated in recurrent tissues from the non-cirrhotic HCC patients (P=0.015) and also in tumor tissues irrespective of tumor stage (P<0.001) or BCLC stage (P<0.001). High mRNA levels of AROS were statistically significantly associated with tumor stage (P<0.001), BCLC stage (P=0.007), alpha fetoprotein (AFP) level (P=0.013), microvascular invasion (P=0.001), tumor size (P=0.036), and portal vein invasion (P=0.005). Kaplan-Meir curve analysis demonstrated that HCC patients with higher AROS levels had shorter disease-free survival (DFS) in both the short-term (P<0.001) and long-term (P=0.005) compared to those with low AROS. Cox regression analysis demonstrated that AROS is a significant predictor for DFS along with large tumor size, tumor multiplicity, vascular invasion, and poor tumor differentiation, which are the known prognostic factors. In conclusion, AROS is a significant biomarker for tumor aggressiveness in non-cirrhotic hepatocellular carcinoma.
Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Factores de Transcripción
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Proteínas Nucleares
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Biomarcadores de Tumor
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Prevalencia
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Reproducibilidad de los Resultados
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Factores de Riesgo
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Sensibilidad y Especificidad
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Distribución por Sexo
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Distribución por Edad
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Carcinoma Hepatocelular
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Journal of Korean Medical Science
Año:
2015
Tipo del documento:
Article