A Novel Aromatic Fluorine-18 Labeling Method Using Iodonium Salts Precursor / 핵의학분자영상
Nuclear Medicine and Molecular Imaging
; : 1-9, 2009.
Article
en Ko
| WPRIM
| ID: wpr-59156
Biblioteca responsable:
WPRO
ABSTRACT
As many new drug substances contained various aromatic rings and fluorine attached to an electron rich aromatic ring or on the meta-position, a strategy towards improvement in aromatic fluorination of these compounds is highly desirable. The introduction of fluorine-18 onto aromatic rings showed in the limited condition containing electron withdrawing group (EWG) on the para- or ortho-position to get reasonable radiochemical yield so far. No-carrier added (NCA) [18F]fluoroarene syntheses by iodonium salts recently reported that has the potential to greatly increase the yield in systems or positions that normally not reactive enough to give sufficient yields in simple model reaction. This review describes the methodological approach towards effective aromatic fluorination by diaryliodonium salts and future prospects in an application of novel PET radiotracer.
Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Sales (Química)
/
Electrones
/
Halogenación
/
Flúor
Idioma:
Ko
Revista:
Nuclear Medicine and Molecular Imaging
Año:
2009
Tipo del documento:
Article