Mechanism of Reduced Urinary Albumin Excretion in Patients with Early Diabetic Nephropathy by Alpha-lipoic Acid / 中国药师

ABSTRACT

Objective:To investigate the effects of alpha-lipoic acid on urinary albumin excretion in the patients with early diabetic nephropathy (DN). Methods:Totally 103 patients with early DN were randomly divided into the control group (n=59) and the treat-ment group ( n=44 ) . The two groups were both treated with dietary control and hypoglycemic drugs. The patients in the treatment group were given alpha-lipoic acid 450 mg·d-1 by intravenous infusion for 10 days on the basis of the initial therapy. The levels of HbA1c, BP, lipids, urinary 8-OHdG, urinary MCP-1 and urinary albumin were determined. Results:Compared with those in the con-trol group, urinary 8-OHdG, MCP-1 and urinary albumin were decreased significantly after alpha-lipoic acid treatment. The changes in HbA1c, BP and lipids were not significant. Conclusion:Aalpha-lipoic acid can decrease urinary albumin and 8-OHdG by lowering the expression of ROS and MCP-1.