Predictive Factors for Decline in Activities of Daily Living in Alzheimer's Disease Dementia with More than 2 Follow-up
Dementia and Neurocognitive Disorders
; : 100-106, 2013.
Article
en Ko
| WPRIM
| ID: wpr-66958
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND:
Impairment in activities of daily living (ADL) is a major problem in Alzheimer's disease (AD), and is related to increased caregiver burden.The present study evaluated whether there are any components of initial dementia evaluation that could predict ADL decline in years follow-up.METHODS:
The 32 subjects underwent more than two consecutive neuropsychological evaluation and maintained anti-dementia medication from the Ewha Dementia Cohort. The first clinical, neuropsychological test results, medial temporal atrophy rating and white matter ratings were correlated with the final ADL scores. The subjects were further divided into ADL-preserved and declined groups for the comparison depending on final ADL scores.RESULTS:
The annual decline of the Korean Mini-mental status examination (K-MMSE) score was 1.5+/-1.2 and of the Seoul-instrumental ADL score was 6.1+/-4.6. The Factors correlated with the ADL at baseline were the clinical dementia rating, K-MMSE, memory function score and the total neuropsychological test score, left medial temporal lobe atrophy rating, and the neuropsychiatric total score. Only the neuropsychological component including total test, frontal and visuospatial function scores were statistically different between the two groups in the baseline evaluation.CONCLUSIONS:
The result of our preliminary study emphasize the other study results that the initial cognitive and dementia status are the strong predictive factors not only for the initial ADL dysfunction but also for the ADL decline in years followed-up dementia cohort.Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Atrofia
/
Lóbulo Temporal
/
Actividades Cotidianas
/
Estudios de Cohortes
/
Estudios de Seguimiento
/
Cuidadores
/
Demencia
/
Enfermedad de Alzheimer
/
Memoria
/
Métodos
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
Ko
Revista:
Dementia and Neurocognitive Disorders
Año:
2013
Tipo del documento:
Article