Radionuclide functional and molecular imaging in rapid eye movement sleep behavior disorder / 中华核医学与分子影像杂志

ABSTRACT

Rapid eye movement sleep behavior disorder (RBD) is a condition characterized by rap id eye movement sleep without atonia and with complex behaviors associated with dreams.Numerous studies have revealed that idiopathic RBD is the prodromal manifestation of neurodegenerative disorders,especially those mediated by α-synuclein.The structural and functional imaging of RBD,including transcranial sonog raphy (TCS),MRI,SPECT,PET,are increasingly becoming the hot issues.This review summarizes the radionuclide imaging in RBD,which may be one of the most promising modalities to detect the biomarkers for early diagnosis of neurodegenerative disorders.