mRNA Expression of SLC5A5 and SLC2A Family Genes in Papillary Thyroid Cancer: An Analysis of The Cancer Genome Atlas
Yonsei Medical Journal
; : 746-753, 2018.
Article
en En
| WPRIM
| ID: wpr-716429
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
The present study investigated the dynamics and prognostic role of messenger RNA (mRNA) expression responsible for 18F-fluorodeoxyglucose (FDG) uptake in FDG positron emission tomography (PET) and radioactive iodine (131I) uptake in whole-body radioactive iodine scans (WBS) in papillary thyroid cancer (PTC) patients. MATERIALS ANDMETHODS:
The primary and processed data were downloaded from the Genomic Data Commons Data Portal. Expression data for sodium/iodide symporter (solute carrier family 5 member 5, SLC5A5), hexokinase (HK1–3), glucose-6-phosphate dehydrogenase (G6PD), and glucose transporter (solute carrier family 2, SLC2A1–4) mRNA were collected.RESULTS:
Expression of SLC5A5 mRNA were negatively correlated with SLC2A1 mRNA and positively correlated with SLC2A4 mRNA. In PTC with BRAF mutations, expressions of SLC2A1, SLC2A3, HK2, and HK3 mRNA were higher than those in PTC without BRAF mutations. Expression of SLC5A5, SLC2A4, HK1, and G6PD mRNA was lower in PTC without BRAF mutation. PTCs with higher expression of SLC5A5 mRNA had more favorable disease-free survival, but no association with overall survival.CONCLUSION:
Expression of SLC5A5 mRNA was negatively correlated with SLC2A1 mRNA. This finding provides a molecular basis for the management of PTC with negative WBS using 18F-FDG PET scans. In addition, higher expression of SLC5A5 mRNA was associated with less PTC recurrence, but not with deaths.Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Recurrencia
/
Glándula Tiroides
/
ARN Mensajero
/
Neoplasias de la Tiroides
/
Genoma
/
Transporte Iónico
/
Supervivencia sin Enfermedad
/
Fluorodesoxiglucosa F18
/
Tomografía de Emisión de Positrones
/
Proteínas Facilitadoras del Transporte de la Glucosa
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Yonsei Medical Journal
Año:
2018
Tipo del documento:
Article