The Prevalence and Clinical Features of Non-responsive Gastroesophageal Reflux Disease to Practical Proton Pump Inhibitor Dose in Korea: A Multicenter Study / 대한소화기학회지
The Korean Journal of Gastroenterology
; : 16-22, 2016.
Article
en En
| WPRIM
| ID: wpr-76278
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND/AIMS:
In Korea, there are no available multicenter data concerning the prevalence of or diagnostic approaches for non-responsive gastroesophageal reflux disease (GERD) which does not respond to practical dose of proton pump inhibitor (PPI) in Korea. The purpose of this study is to evaluate the prevalence and the symptom pattern of non-responsive GERD.METHODS:
A total of 12 hospitals who were members of a Korean GERD research group joined this study. We used the composite score (CS) as a reflux symptom scale which is a standardized questionnaire based on the frequency and severity of typical symptoms of GERD. We defined "non-responsive GERD" as follows a subject with the erosive reflux disease (ERD) whose CS was not decreased by at least 50% after standard-dose PPIs for 8 weeks or a subject with non-erosive reflux disease (NERD) whose CS was not decreased by at least 50% after half-dose PPIs for 4 weeks.RESULTS:
A total of 234 subjects were analyzed. Among them, 87 and 147 were confirmed to have ERD and NERD, respectively. The prevalence of non-responsive GERD was 26.9% (63/234). The rates of non-responsive GERD were not different between the ERD and NERD groups (25.3% vs. 27.9%, respectively, p=0.664). There were no differences between the non-responsive GERD and responsive GERD groups for sex (p=0.659), age (p=0.134), or BMI (p=0.209). However, the initial CS for epigastric pain and fullness were higher in the non-responsive GERD group (p=0.044, p=0.014, respectively).CONCLUSIONS:
In conclusion, this multicenter Korean study showed that the rate of non-responsive GERD was substantially high up to 26%. In addition, the patients with the non-responsive GERD frequently showed dyspeptic symptoms such as epigastric pain and fullness.Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Protones
/
Esofagitis Péptica
/
Reflujo Gastroesofágico
/
Prevalencia
/
Bombas de Protones
/
Inhibidores de la Bomba de Protones
/
Ácido Gástrico
/
Pirosis
/
Corea (Geográfico)
Tipo de estudio:
Clinical_trials
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
The Korean Journal of Gastroenterology
Año:
2016
Tipo del documento:
Article