Mesenchymal Stem Cells Ameliorate Renal Inflammation in Adriamycin-induced Nephropathy
Immune Network
; : e36-2019.
Article
en En
| WPRIM
| ID: wpr-764024
Biblioteca responsable:
WPRO
ABSTRACT
Mesenchymal stem cells (MSCs) ameliorate the renal injury in Adriamycin (ADR)-induced nephropathy, but the mechanisms underlying their efficacy remain incompletely understood. In this study, we demonstrated that MSCs increased the survival, recovered body weight loss, and decreased proteinuria and serum creatinine levels in ADR-treated mice. MSCs also prevented podocyte damage and renal fibrosis by decreasing the expression of fibronectin, collagen 1α1, and α-smooth muscle actin. From a mechanistic perspective, MSCs inhibited renal inflammation by lowering the expression of CCL4, CCL7, CCL19, IFN-α/β, TGF-β, TNF-α, and chitinase 3-like 1. In summary, our data demonstrate that MSCs improve renal functions by inhibiting renal inflammation in ADR-induced nephropathy.
Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Proteinuria
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Peso Corporal
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Fibrosis
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Doxorrubicina
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Quitinasas
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Actinas
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Colágeno
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Fibronectinas
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Creatinina
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Podocitos
Límite:
Animals
Idioma:
En
Revista:
Immune Network
Año:
2019
Tipo del documento:
Article