Anti-inflammatory effects of a Houttuynia cordata supercritical extract
Journal of Veterinary Science
; : 273-275, 2010.
Article
en En
| WPRIM
| ID: wpr-79609
Biblioteca responsable:
WPRO
ABSTRACT
Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in a carrageenan-air pouch model. HSE (200 mg/kg, oral) suppressed exudation and albumin leakage, as well as inflammatory cell infiltration. Dexamethasone (2 mg/kg, i.p.) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content. HSE lowered tumor-necrosis factor (TNF)-alpha and nitric oxide (NO), as well as prostaglandin E2 (PGE2). Dexamethasone only reduced TNF-alpha and NO, while indomethacin decreased TNF-alpha and PGE2. The suppressive activity of HSE on NO and PGE2 production was confirmed in RAW 264.7. These results demonstrate that HSE exerts anti-inflammatory effects by inhibiting both TNF-alpha-NO and cyclooxygenase II-PGE2 pathways.
Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Dexametasona
/
Medicamentos Herbarios Chinos
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Dinoprostona
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Transducción de Señal
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Carragenina
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Indometacina
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Análisis de Varianza
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Técnicas para Inmunoenzimas
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Factor de Necrosis Tumoral alfa
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Línea Celular Tumoral
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Journal of Veterinary Science
Año:
2010
Tipo del documento:
Article