Evaluating in vitro effect of 10 alpha-trifluoro methyl hydroartemisinin in powder and tablet form to P.falciparum
Journal of Malaria and parasite diseases Control
; : 56-60, 2004.
Article
en Vi
| WPRIM
| ID: wpr-819
Biblioteca responsable:
WPRO
ABSTRACT
Background:
WHO recommends that malaria drug should be used with essential elements which are derivatives of artemisinin (ART) for treatment phase and limit the development of parasite (MIC).Objective:
To assess in vitro effect of artemisinin powder and 10 alpha- trifluoro methyl hydroartemisinin (TEMHA) in powder and tablet form to P.falciparum. Subject andMethod:
48h in vitro test of Phuc Nguyen Dinh was applied to this study. Results andConclusions:
The results showed that for T996, IC50 values of ART, 10 alpha- TEMHA powder and 10 alpha- TEMHA pill were as follows 37.8; 16.4 and 17.6 nM/L, respectively. For K1, IC50 values of ART, 10 alpha- TEMHA powder and 10 alpha- TEMHA pill were 22.8; 11.4 and 12.2 nM/L, respectively. MIC values of artemisinin powder, 10 alpha- TEMHA powder and pill for T996 were as follows 100; 40 and 40nM/L, respectively. For K1, MIC values of ART, 10 alpha- TEMHA powder and pill are 76; 24; 32 nM/L, respectively.
Texto completo:
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Banco de datos:
WPRIM
Idioma:
Vi
Revista:
Journal of Malaria and parasite diseases Control
Año:
2004
Tipo del documento:
Article