RESUMEN
The catalytic reactions of indoles with CO2 and phenylsilane afforded indolo[3,2-b]carbazoles, where the fused benzene ring was constructed by forming two C-H bonds and four C-C bonds with two CO2 molecules via deoxygenative conversions. Nine-membered cyclophanes made up of three indoles and three CO2 molecules were also obtained, where the cyclophane framework was constructed by forming six C-H bonds and six C-C bonds. These multicomponent cascade reactions giving completely different carbocycles were switched simply by choosing the solvent, acetonitrile or ethyl acetate.
RESUMEN
BPh3 catalyzes the N-methylation of secondary amines and the C-methylenation (methylene-bridge formation between aromatic rings) of N,N-dimethylanilines or 1-methylindoles in the presence of CO2 and PhSiH3 ; these reactions proceed at 30-40 °C under solvent-free conditions. In contrast, B(C6 F5 )3 shows little or no activity. 11 Bâ NMR spectra suggested the generation of [HBPh3 ]- . The detailed mechanism of the BPh3 -catalyzed N-methylation of N-methylaniline (1) with CO2 and PhSiH3 was studied by using DFT calculations. BPh3 promotes the conversion of two substrates (N-methylaniline and CO2 ) into a zwitterionic carbamate to give three-component species [Ph(Me)(H)N+ CO2 - â â â BPh3 ]. The carbamate and BPh3 act as the nucleophile and Lewis acid, respectively, for the activation of PhSiH3 to generate [HBPh3 ]- , which is used to produce key CO2 -derived species, such as silyl formate and bis(silyl)acetal, essential for the N-methylation of 1. DFT calculations also suggested other mechanisms involving water for the generation of [HBPh3 ]- species.