RESUMEN
Dermatomyositis (DM) is a systemic autoimmune disorder characterized by proximal myopathy and dermatological findings. Approximately 15-30% of DM cases emerge as a paraneoplastic syndrome caused by a concomitant malignancy. Although more rare, in cancer patients DM has also been reported as a possible result of toxicity of some antineoplastic agents, such as taxanes and monoclonal antibodies. Herein, we report a 35-year-old woman with metastatic breast cancer who presented with skin lesions after initiation of paclitaxel and anti-HER2 agents. Clinical, laboratory, and histological findings were consistent with the diagnosis of DM.
Asunto(s)
Neoplasias de la Mama , Dermatomiositis , Femenino , Humanos , Adulto , Anticuerpos Monoclonales , Autoanticuerpos , PaclitaxelRESUMEN
Myopericytoma is an uncommon benign neoplasm that arises from the perivascular myoid cells. It typically presents as a painless well-circumscribed cutaneous or soft-tissue nodule, most commonly on the extremities of adults. Histologically, it is characterized by spindle-shaped myoid-appearing cells with a concentric arrangement in vessel walls, that are immunoreactive to alpha-smooth muscle actin and often for h-caldesmon, but negative for other smooth muscle markers. Herein, we present an unusual case of a painful subungual myopericytoma presenting as a dark subungual discoloration.
Asunto(s)
Hemangiopericitoma , Myopericytoma , Enfermedades de la Uña , Adulto , Hemangiopericitoma/patología , Humanos , Myopericytoma/patología , Enfermedades de la Uña/diagnóstico , Enfermedades de la Uña/patología , Pericitos/patología , Piel/patologíaRESUMEN
A 76-year-old woman presented to the medical oncology outpatient clinic with painful, burning, pruritic erythematous plaques involving both palms and axillae that had suddenly appeared five days before. Examination revealed no additional relevant findings and laboratory studies did not show any alteration. The patient had been recently diagnosed with a high-grade angiosarcoma of the breast (probably radiation induced) and after frequent local recurrences, was being treated with liposomal doxorubicin (three cycles were administered, the last of which was seven days before the appearance of the mentioned lesions). Oral corticosteroids were started, treatment with liposomal doxorubicin was stopped, and cutaneous biopsies performed that revealed features compatible with toxic erythema of chemotherapy induced by liposomal doxorubicin. Complete resolution of the cutaneous lesions was verified one month after. No signs of recurrence of angiosarcoma were documented at follow-up three months later.
Asunto(s)
Antineoplásicos , Hemangiosarcoma , Anciano , Doxorrubicina/efectos adversos , Doxorrubicina/análogos & derivados , Eritema/inducido químicamente , Femenino , Humanos , PolietilenglicolesAsunto(s)
Alopecia/diagnóstico , Alopecia/etiología , Alopecia/terapia , Femenino , Humanos , Tracción/efectos adversos , Adulto JovenAsunto(s)
Alopurinol/efectos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Cladribina/efectos adversos , Erupciones por Medicamentos/fisiopatología , Exantema/inducido químicamente , Leucemia de Células Pilosas/tratamiento farmacológico , Trastornos de la Pigmentación/inducido químicamente , Trastornos de la Pigmentación/tratamiento farmacológico , Púrpura/inducido químicamente , Púrpura/tratamiento farmacológico , Anciano , Alopurinol/uso terapéutico , Antimetabolitos Antineoplásicos/efectos adversos , Antimetabolitos Antineoplásicos/uso terapéutico , Antineoplásicos/efectos adversos , Antineoplásicos/uso terapéutico , Cladribina/uso terapéutico , Erupciones por Medicamentos/prevención & control , Monitoreo de Drogas , Exantema/fisiopatología , Exantema/prevención & control , Humanos , Masculino , Trastornos de la Pigmentación/fisiopatología , Trastornos de la Pigmentación/prevención & control , Púrpura/fisiopatología , Púrpura/prevención & control , Índice de Severidad de la Enfermedad , Resultado del TratamientoRESUMEN
Acral persistent papular mucinosis is a subtype of localized lichen myxedematosus. It presents as acrally located papules with a benign, but persistent course. It is a scarcely reported disease. We present a female with both the clinical and histopathological described criteria.
Asunto(s)
Escleromixedema/diagnóstico , Brazo , Dermis/química , Diagnóstico Diferencial , Femenino , Dermatosis de la Mano/diagnóstico , Dermatosis de la Mano/patología , Humanos , Persona de Mediana Edad , Mucinas/análisis , Escleromixedema/patologíaRESUMEN
Human leishmaniasis produced by Leishmania infantum is endemic in Mediterranean countries. In the context of a leishmaniasis outbreak in the town of Fuenlabrada, Madrid, Spain, we had two patients with cutaneous leishmaniasis that developed non-necrotizing cutaneous granulomas. They had both been receiving anti-TNF treatment with adalimumab for rheumatic diseases. Neither of them developed visceral disease and did not require anti-TNF treatment withdrawal to control the cutaneous disease. It is well known that anti-TNF therapy is associated with opportunistic diseases, especially with those in which granuloma formation is an important part of the host defence, as in tuberculosis. We think that granuloma formation through activation of Toll-like receptor-9 and via induction of a Th17 response may be precipitated by the parasites in the dermis.