1.
J Org Chem
; 88(24): 17172-17180, 2023 Dec 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38014885
RESUMEN
A concise and stereoselective total synthesis of (-)-hedycoropyran A was accomplished in a substrate-controlled manner from a readily available alkene. Highlights of the synthesis include a highly diastereoselective dehydrogenative cycloetherification to construct the trans-2-aryl-6-alkyl-3,6-dihydro-2H-pyran framework and late-stage substrate-controlled trans-dihydroxylation at C(3,4).