Asunto(s)
Enfermedades Cardiovasculares , Hidradenitis Supurativa , Biomarcadores , Enfermedades Cardiovasculares/etiología , Factores de Riesgo de Enfermedad Cardiaca , Hidradenitis Supurativa/complicaciones , Humanos , Inflamación/complicaciones , Factores de Riesgo , Índice de Severidad de la EnfermedadAsunto(s)
COVID-19 , Dermatología , Humanos , Calidad de Vida , SARS-CoV-2 , Encuestas y CuestionariosAsunto(s)
Atención a la Salud/normas , Eccema/terapia , Niño , Preescolar , Auditoría Clínica , Manejo de la Enfermedad , Eccema/diagnóstico , Femenino , Adhesión a Directriz/normas , Humanos , Lactante , Recién Nacido , Masculino , Reino UnidoRESUMEN
BACKGROUND: Chronic plaque psoriasis can be subdivided into two groups according to the age of onset: type 1 (early onset, before 40 years) and type 2 (late onset, at or beyond 40 years). So far, 36 genetic loci have been associated with early-onset psoriasis in genome-wide association studies of white populations, while few studies have investigated genetic susceptibility to late-onset psoriasis. OBJECTIVES: To characterize the genetics underpinning late-onset psoriasis. METHODS: We genotyped 543 cases of late-onset psoriasis and 4373 healthy controls using the Immunochip array, a dense genotyping chip containing single-nucleotide polymorphisms previously associated with autoimmune diseases. Imputation using SNP2HLA and stepwise logistic regression analysis was performed for markers spanning the human leucocyte antigen gene region. RESULTS: Two loci (HLA-C and IL12B) previously associated with early-onset psoriasis showed significant association at a genome-wide threshold in the current study (P < 5 × 10(-8)). Six more loci (TRAF3IP2, IL23R, RNF114, IFIH1, IL23A and HLA-A) showed study-wide significant association (P < 2·3 × 10(-5); calculated using Genetic type 1 error calculator). Additionally, we identified an association at IL1R1 on chromosome 2q13, which is not associated with early-onset disease. CONCLUSIONS: This is the largest study to date of genetic loci in late-onset psoriasis, and demonstrates the overlap that exists with early-onset psoriasis. It also suggests that some loci are associated exclusively with late-onset psoriasis.