RESUMEN
PURPOSE: Cancer-related pain is primarily treated with opioids which while effective can add significant patient burden due to side effects, associated stigma, and timely access. The purpose of this perspective discussion is to argue for a precision approach to pain in cancer based on a biopsychosocial and spiritual model which we argue can offer a higher quality of life while limiting opioid use. CONCLUSIONS: Pain in cancer represents a heterogenous process with multiple contributing and modulating factors. Specific characterization of pain as either nociceptive, neuropathic, nociplastic, or mixed can allow for targeted treatments. Additional assessment of biopsychosocial and spiritual issues can elucidate further points of targeted intervention which can lead to overall greater pain control.Implications for RehabilitationPrecision Pain Management in CancerPain in cancer is complex and heterogeneous with multiple contributing etiologies.A comprehensive assessment addressing the biopsychosocial and spiritual aspects of pain may lead to better control.Utilizing multiple targeted treatment strategies may help to curb opioid use.