Dynamics of improvement following total lumbar disc replacement: is the outcome predictable?

STUDY DESIGN: Prospective clinical study of total lumbar disc replacement (TDR) with ProDisc II (Synthes, Paoli, PA). OBJECTIVES: To examine whether baseline variables VAS (Visual Analogue Scale) and ODI (Oswestry Disability Index) correspond with late and final postoperative outcome parameters and to identify early predictors of late outcome following total lumbar disc replacement (TDR). SUMMARY OF BACKGROUND DATA: Previously published TDR studies reported on the pooled data averages collected from various cohort sizes. The individual patient's prognosis as well as prognostic factors of postoperative improvement remain unestablished. METHODS: Data were accumulated prospectively and included VAS and ODI scores. The subjective outcome evaluation was based on a 3-scale grading system ("highly satisfied," "satisfied," "not satisfied"). An analysis was performed to ascertain whether the late and final outcome following TDR can be predicted based on preoperative and early postoperative data from the 3 and 6 month follow-up (FU). RESULTS: The overall results from 161 patients with an average FU of 4 years (mean: 45.5 months, range: 24.1-94.4 months) revealed a significant and maintained improvement of VAS and ODI scores (P < 0.0001). The most pronounced changes occurred within the early postoperative period (P < 0.0001) with no significant changes thereafter (P > 0.05).Baseline ODI levels were significantly correlated with VAS/ODI scores and patient satisfaction rates at the final FU (P < 0.0001).After surgery, early and late ODI levels were highly significantly correlated with each other (r = 0.84, P < 0.0001). Similar associations were observed between early and late VAS scores and patient satisfaction rates (P < 0.006).The individual patient's subjective outcome evaluation revealed stable postoperative results. An improvement or a deterioration by 2 classes on a 3-scale grading system was only observed in 3.1% (n = 5/161) of all cases overall. Patients with an early "highly satisfactory" result (n = 83) maintained either a satisfactory (15.7%, n = 13/83) or a highly satisfactory outcome (79.5%, n = 66/83) in 95.2% of all cases (n = 79/83).Conversely, the probability that patients with an "unsatisfactory" outcome would still achieve a "highly satisfactory" result after the early postoperative period was 5.0%. CONCLUSION: Baseline ODI and early postoperative outcome parameters (< or =6 months) revealed significant and strong associations with the final results following TDR. While the vast majority of patients with an early highly satisfactory outcome maintained satisfactory results at later FU stages, any significant improvement considered as "highly satisfied" is unlikely in a group of patients which reported early unsatisfactory results. In summary, any clinically relevant changes are unlikely to occur after the early postoperative period.The current findings offer a foundation for weighing both the patients and the spine surgeons expectations against possible realistic achievements. Although the data show that the midterm outcome at a FU of 4 years (mean: 45.5 months, range: 24.1-94.4 months) is predictable following TDR, the long-term results of lumbar disc replacements still need to be established.

Combined Abdominal and Spine Injuries after High Energy Flexion-Distraction Trauma.

Combined abdominal (AT) and spine (ST) trauma in the multiply traumatized patient (MT) requires optimal clinical management. At the Traumacenter Murnau, Germany all multiply injured patients (injury severity score ≥ 16) are registered in a large prospective database (DGU-Tramaregister). From 1 January 2002 until 31 December 2004, 731 multiply injured patients (ISS ≥ 16) were admitted to the Trauma Center Murnau. In this population, ST was diagnosed in 287 patients (39%), AT was diagnosed in 100 patients (14%), and in 35 patients (5%) a combined ST and AT was observed. The most frequent injury mechanism in patients with a combined ST and AT was high-energy flexion-distraction trauma caused by motor vehicle accident with seat belt fastened passengers, bicycle accident, and fall from great height. In the cohort group of 35 patients, 29 required either abdominal or spinal operation. In 23 patients the AT and in 18 patients the ST necessitated operation. In 14 patients both the AT and ST called for surgery. The AT was predominately treated with splenectomies, resections and suturing of the intestine. The ST resulted in 14 posterior and four postponed anterior stabilizations of the thoracolumbar and four anterior fusions of the cervical spine. Mean age of these patients was 37 years in comparison to 47 years in the control group (MT without combined AT and ST). ISS of patients with combined AT and ST was 38 points compared to 26 points in the control group, and mortality was 7% in the combined group compared to 14% in the control group. The present study documents that damage control principles applied to patients sustaining the complex combination of AT and ST can result in low mortality rates despite the severity of this injury.

Strategies for prevention and operative treatment of aortic lesions related to spinal interventions.

STUDY DESIGN: A retrospective analysis of a case series was performed. OBJECTIVE: To give recommendations for the prevention and operative treatment of thoracic and thoracoabdominal aortic lesions in association with spinal interventions. SUMMARY OF BACKGROUND DATA: Aortic lesions after spinal interventions for traumatic vertebral fractures, segmental spondylodiscitis, or vertebral metastasis are fortunately rare, but associated with a high perioperative mortality rate and absolute numbers are unknown. Therefore, preventive strategies to avoid perioperative major vessel injuries and recommendations for the operative treatment of aortic lesions related to spinal surgery are required. METHODS: The clinical course of 10 patients with an acute aortic hemorrhage or an increased intraoperative risk for aortic injuries in association with primary or secondary spinal interventions is reported. All patients were evaluated before surgery by orthopedic trauma surgeons, vascular surgeons, and diagnostic radiologists. RESULTS: Five patients had preventive vascular interventions to avoid major aortic injuries during spinal reinterventions, and 5 patients were treated as an emergency for acute intraoperative hemorrhage related to spinal interventions. The operative treatment was performed by direct aortic sutures (n = 3), segmental alloplastic reconstructions (n = 2), or endovascular stent graft implantations (n = 3). Prophylactic banding of the thoracic aorta during thoracotomy or a femoral access for possible aortic balloon blockade was performed in patients with an estimated lower risk for an aortic laceration caused by malpositioned pedicle screws. No perioperative mortality was observed in patients treated by this interdisciplinary concept, but 1 patient treated under emergency condition for spondylodiscitis with an initially unrecognized aortic lesion died. CONCLUSION: In patients with complex spinal trauma, spondylodiscitis or difficult vertebral reinterventions, and an increased risk of major vessel injury, a preoperative interdisciplinary evaluation is recommended, even under emergency conditions. Endovascular stent graft technique is an additional option for prevention and treatment of suspected or acute aortic injuries of thoracic and infrarenal aortic lesions, whereas injuries to the visceral aortic segment still require advanced vascular reconstructions.