RESUMEN
Calcium-aluminium-phosphate cements (CAPCs) for biomedical applications, mainly intended for applications in the dental field as non-resorbable fillers, were obtained by reacting Ca-aluminates compounds, i.e. CaO·Al(2)O(3) (CA) and CaO·2 Al(2)O(3) (CA(2)), with Al(H(2)PO(4))(3) aqueous solution. Hydroxyapatite was also introduced as a bioactive dispersed phase. Suitable elements like Sr and La were used to increase the radiopacity of the set yielded pastes towards X-ray wavelength used in clinical diagnostic radiographic equipments. La and Sr doped Ca-aluminates powders have been synthesized by solid state reaction at 1,400°C from a mixture of CaCO(3), Al(2)O(3), La(2)O(3) and SrCO(3). The characteristics of the obtained powders were analyzed and related to the starting compositions and synthesis procedures. The microstructure, setting time, radiopacity and compressive strength of the CAPCs have been investigated and discussed.
Asunto(s)
Compuestos de Aluminio/química , Materiales Biocompatibles/química , Fosfatos de Calcio/química , Cementos para Huesos/química , Calcio/química , Compuestos de Calcio/química , Carbonatos/química , Durapatita/química , Lantano/química , Ensayo de Materiales , Óxidos/química , Polvos , Estroncio/química , Temperatura , Difracción de Rayos XRESUMEN
BACKGROUND: A familial predisposition to colorectal cancer (CRC) has been clearly established, consisting of familial clustering in 15-20% and clear hereditary aetiology in 5-10% of overall CRC cases. Early identification of families and individuals at high risk is essential as intensive surveillance has been demonstrated to reduce cancer incidence and overall mortality. In the present study, the value of oral mucosal light reflectance in identifying hereditary non-polyposis colorectal cancer (HNPCC) carriers was investigated. METHODS: Twenty members of six different genetically unrelated HNPCC kindred and 30 genetically unrelated age and sex matched healthy controls were examined. Lower gingival and vestibular oral mucosal reflectance was measured using an imaging spectrophotometer. RESULTS: HNPCC carriers showed significantly lower values in the 590-700 nm wavelength range (pAsunto(s)
Neoplasias Colorrectales Hereditarias sin Poliposis/diagnóstico
, Mucosa Bucal
, Espectrofotometría/métodos
, Proteínas Adaptadoras Transductoras de Señales/genética
, Estudios de Casos y Controles
, Neoplasias Colorrectales Hereditarias sin Poliposis/genética
, Reparación de la Incompatibilidad de ADN
, Femenino
, Mutación de Línea Germinal
, Humanos
, Inmunohistoquímica
, Masculino
, Persona de Mediana Edad
, Homólogo 1 de la Proteína MutL
, Proteínas Nucleares/genética
, Factores de Riesgo
RESUMEN
A secondary ion mass spectrometry (SIMS) study of Zr- and Ti-based borides is reported: ZrB2 ceramic samples (with and without nickel addition) and a TiB2-Ni-B4C/Cu joint were investigated. For Zr-based samples, SIMS measurements show evidence for induced effects by the presence of nickel with regard to oxygen and hydrogen absorption and zirconia formation. In the case of the TiB2-Ni-B4C/Cu joint, the ceramic-metal interface region was analysed and the extent of Cu diffusion into the ceramic material was established. SIMS results were in agreement with previously obtained SEM-EDS data.