Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Más filtros

Base de datos
Tipo del documento
Asunto de la revista
País de afiliación
Intervalo de año de publicación
1.
J Low Genit Tract Dis ; 18(4): 347-50, 2014 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-25259595

RESUMEN

INTRODUCTION: Our objective was to evaluate the efficacy of conservative treatment with imiquimod in Paget vulvar disease. MATERIALS AND METHODS: We describe a case series that includes 10 patients with histopathologic diagnosis of extramammary Paget disease of the vulva, who were treated with 5% imiquimod cream. Of these patients, 3 were treated for recurrent disease and 7 were treated for initial primary disease. The patients applied the cream every other day until the lesions were no longer clinically detected.They were previously instructed on how and where to apply the cream by making them use a mirror while following the physician's directions. RESULTS: Complete clinical and histologic remission of the disease was achieved in 9 patients. The remaining patient had partial histologic response and is still under treatment. The treatment was well tolerated despite moderate irritation. No recurrences were observed during a mean follow-up of 18 months. CONCLUSIONS: On the basis of the results, the authors consider that 5% imiquimod cream could be considered a safe and effective therapeutic option for the treatment of primary vulvar Paget disease. Further studies are needed to determine the real efficacy and safety of 5% imiquimod cream for the treatment of this infrequent disease.


Asunto(s)
Aminoquinolinas/uso terapéutico , Antineoplásicos/uso terapéutico , Enfermedad de Paget Extramamaria/tratamiento farmacológico , Neoplasias de la Vulva/tratamiento farmacológico , Administración Tópica , Anciano , Anciano de 80 o más Años , Aminoquinolinas/efectos adversos , Femenino , Humanos , Imiquimod , Persona de Mediana Edad , Crema para la Piel/efectos adversos , Crema para la Piel/uso terapéutico , Resultado del Tratamiento
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA