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1.
Palliat Support Care ; 14(2): 161-73, 2016 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-26063219

RESUMEN

OBJECTIVE: Ensuring a consistent and systematic approach to the delivery of care for people with advanced disease is a priority for palliative care services worldwide. Many clinical tools are available to aid in this process; however, they are often used sporadically, and implementation of a routine set of clinical tools to guide care planning in the specialist palliative care sector in Australia has not been achieved. This study sought to recommend key clinical tools that may assist with the assessment and care planning of specialist palliative care provision for patients and family caregivers admitted to specialist palliative care settings (home, hospital, and hospice). METHOD: A mixed-methods sequential approach over four phases was employed, involving: (1) a palliative care sector survey, (2) a systematic literature review, (3) an appraisal of identified clinical tools, and (4) a focus group with an expert panel who critiqued and endorsed a final suite of clinical tools recommended for specialist palliative care. RESULTS: Twelve tools with practical relevance were recommended for use across settings of care. SIGNIFICANCE OF RESULTS: Palliative services should review current practices and seek to implement this recommended suite of tools to enhance assessment and guide care delivery across care settings. Subsequent evaluation should also occur.


Asunto(s)
Atención a la Salud/métodos , Atención a la Salud/normas , Planificación en Salud/métodos , Cuidados Paliativos/métodos , Australia , Grupos Focales , Humanos , Revisiones Sistemáticas como Asunto
3.
Eur J Cancer Care (Engl) ; 25(1): 190-201, 2016 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-25904221

RESUMEN

The aim of this study was to explore reasons for the hospitalisation and place of death outcomes of terminal cancer patients. The methodology involved a qualitative content analysis of medical records pertaining to the last 3 months of life of 39 patients with one of four malignancies: prostate, breast, lung, or haematological. The results presentation is organised around three themes: decision hierarchy in health care, meanings of 'home', and late recognition of dying. Based on the detailed findings, this paper suggests that important insights into the broader goals of advanced cancer patients are offered by allied health staff, and that more effective use of the multidisciplinary team may support endeavours to achieve more home deaths for cancer patients who want this outcome. The analysis also provides new insights into the meaning of 'home' in interactions between advanced cancer patients and health professionals. The wish for 'home' appears bound up with other patient goals and the implications of this are discussed.


Asunto(s)
Atención a la Salud/organización & administración , Servicios de Atención de Salud a Domicilio , Hospitalización , Neoplasias/terapia , Cuidado Terminal/organización & administración , Adulto , Anciano , Anciano de 80 o más Años , Actitud Frente a la Muerte , Toma de Decisiones , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neoplasias/psicología , Prioridad del Paciente , Investigación Cualitativa , Victoria
4.
Aust Fam Physician ; 44(7): 479-84, 2015 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-26590493

RESUMEN

BACKGROUND: There is a belief that end-of-life care issues are similar for all cancer patients, irrespective of their primary cancer diagnosis. This exploratory study into the terminal trajectories of three common cancers challenges this belief. METHODS: A retrospective, systematic, and mixed qualitative and quantitative medical record review of 30 deceased patients in 2010 was performed between two Victorian networks. The last 90 days of life were examined in three equally distributed cancer groups - prostate, lung and haematological. RESULTS: The trajectories for the three malignancies differed in temporal, symptomatic, supportive and interventional characteristics. DISCUSSION: Our study suggests diagnosis does indeed matter. The varying symptomatology for the different cancers markedly influenced clinical management, utilisation of palliative care services and the site of care and site of death. Our study suggests potential areas for better collaboration between general practitioners, community and specialist palliative care services. Emerging work supports our findings, but this area warrants further research.


Asunto(s)
Neoplasias Hematológicas/terapia , Neoplasias Pulmonares/terapia , Cuidados Paliativos , Neoplasias de la Próstata/terapia , Cuidado Terminal , Anciano , Anciano de 80 o más Años , Femenino , Medicina General , Neoplasias Hematológicas/diagnóstico , Humanos , Comunicación Interdisciplinaria , Neoplasias Pulmonares/diagnóstico , Masculino , Persona de Mediana Edad , Neoplasias de la Próstata/diagnóstico , Estudios Retrospectivos
5.
Med J Aust ; 202(3): 139-43, 2015 Feb 16.
Artículo en Inglés | MEDLINE | ID: mdl-25669476

RESUMEN

OBJECTIVES: To investigate the quality of end-of-life care for patients with metastatic non-small cell lung cancer (NSCLC). DESIGN AND PARTICIPANTS: Retrospective cohort study of patients from first hospitalisation for metastatic disease until death, using hospital, emergency department and death registration data from Victoria, Australia, between 1 July 2003 and 30 June 2010. MAIN OUTCOME MEASURES: Emergency department and hospital use; aggressiveness of care including intensive care and chemotherapy in last 30 days; palliative and supportive care provision; and place of death. RESULTS: Metastatic NSCLC patients underwent limited aggressive treatment such as intensive care (5%) and chemotherapy (< 1%) at the end of life; however, high numbers died in acute hospitals (42%) and 61% had a length of stay of greater than 14 days in the last month of life. Although 62% were referred to palliative care services, this occurred late in the illness. In a logistic regression model adjusted for year of metastasis, age, sex, metastatic site and survival, the odds ratio (OR) of dying in an acute hospital bed compared with death at home or in a hospice unit decreased with receipt of palliative care (OR, 0.25; 95% CI, 0.21-0.30) and multimodality supportive care (OR, 0.65; 95% CI, 0.56-0.75). CONCLUSION: Because early palliative care for patients with metastatic NSCLC is recommended, we propose that this group be considered a benchmark of quality end-of-life care. Future work is required to determine appropriate quality-of-care targets in this and other cancer patient cohorts, with particular focus on the timeliness of palliative care engagement.


Asunto(s)
Carcinoma de Pulmón de Células no Pequeñas/secundario , Neoplasias Pulmonares/terapia , Cuidados Paliativos/normas , Calidad de la Atención de Salud , Cuidado Terminal/normas , Antineoplásicos/uso terapéutico , Neoplasias Óseas/secundario , Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico , Carcinoma de Pulmón de Células no Pequeñas/terapia , Estudios de Cohortes , Cuidados Críticos , Servicio de Urgencia en Hospital , Femenino , Estudios de Seguimiento , Cuidados Paliativos al Final de la Vida/normas , Hospitalización , Humanos , Tiempo de Internación , Neoplasias Pulmonares/tratamiento farmacológico , Metástasis Linfática/patología , Masculino , Persona de Mediana Edad , Alta del Paciente , Estudios Retrospectivos , Tasa de Supervivencia , Victoria
6.
Stud Hist Philos Biol Biomed Sci ; 39(1): 109-19, 2008 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-18331958

RESUMEN

In the mid-1990s, the company Human Genome Sciences submitted three potentially revolutionary patent applications to the US Patent and Trademark Office, each of which claimed the entire genome sequence of a microorganism. The patent examiners, however, objected to these applications, and after negotiation they were eventually re-written to resemble more traditional gene patents. In this paper, which is based on a study of the patent examination files, we examine the reasons why these patent applications were unsuccessful in their original form. We show that with respect to utility and novelty, the patent attorney's case built on an understanding of the genome as a computer-related invention. The patent examiners did not object to the patenting of complete genome sequences as computer-related inventions on moral grounds or in terms of the distinction between a discovery and an invention. Instead, their objections were based on classification, rules and procedure. Rather than patent examiners having a notion of a genome that should not be patented, the notion of a 'genome', and the ways in which it may be different from a 'gene', played no role in these debates. We discuss the consequences of our findings for patenting in the biosciences.


Asunto(s)
Genómica/historia , Propiedad Intelectual , Patentes como Asunto/historia , Historia del Siglo XX , Humanos , Estados Unidos
7.
Community Genet ; 9(3): 190-6, 2006.
Artículo en Inglés | MEDLINE | ID: mdl-16741349

RESUMEN

Current knowledge about the variety and complexity of the processes that allow regulated gene expression in living organisms calls for a new understanding of genes. A 'postgenomic' understanding of genes as entities constituted during genome expression is outlined and illustrated with specific examples that formed part of a survey research instrument developed by two of the authors for an ongoing empirical study of conceptual change in contemporary biology.


Asunto(s)
Perfilación de la Expresión Génica , Regulación de la Expresión Génica , Genómica/tendencias , Humanos
8.
Nat Rev Genet ; 6(6): 502-6, 2005 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-15883589

RESUMEN

Gene patenting is now a familiar commercial practice, but there is little awareness that several patents claim ownership of the complete genome sequence of a prokaryote or virus. When these patents are analysed and compared to those for other biological entities, it becomes clear that genome patents seek to exploit the genome as an information base and are part of a broader shift towards intangible intellectual property in genomics.


Asunto(s)
Genoma Bacteriano , Genoma Viral , Genómica/legislación & jurisprudencia , Patentes como Asunto
14.
Science ; 295(5564): 2344, 2002 Mar 29.
Artículo en Inglés | MEDLINE | ID: mdl-11923500
15.
Science ; 295(5558): 1212, 2002 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-11847317
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