Biomechanical properties of adjustable extracortical graft fixations in ACL reconstruction.

BACKGROUND: Reliable biomechanical data about the strength of different tibial extracortical graft fixation devices is sparse. This biomechanical study compares the properties of tibial graft fixation in ACL reconstruction with either the ACL Tight Rope™ or the Rigid Loop Adjustable™ device. The hypothesis was that both fixation devices would provide comparable results concerning gap formation during cyclic loading and ultimate failure load. METHODS: Sixteen sawbone tibiae (Sawbones™) underwent extracortical fixation of porcine flexor digitorum profundus grafts for ACL reconstruction. Either the ACL Tight Rope™ (Arthrex) or the Rigid Loop Adjustable™ (DePuy Mitek) fixation device were used, resulting in 2 groups with 8 specimens per group. Biomechanical analysis included pretensioning the constructs 10 times with 0.75 Hz, then cyclic loading of 1,000 position-controlled cycles and 1,000 force-controlled cycles applied with a servohydraulic testing machine. Elongation during cyclic loading was recorded. After this, ultimate failure load and failure mode analysis were performed. RESULTS: No statistically significant difference could be noted between the groups regarding gap formation during cyclic loading (4.6 ± 2.6 mm for the Rigid Loop Adjustable™ vs. 6.6 ± 1.5 mm for the ACL Tight Rope™ (p > 0.05)), and ultimate failure loads (980 ± 101.9 N for the Rigid Loop Adjustable™ vs. 861 ± 115 N ACL Tight Rope™ (p > 0.05)). CONCLUSION: ACL Tight Rope™ and the Rigid Loop Adjustable™ fixation devices yield comparable biomechanical results for tibial extracortical graft fixation in ACL reconstruction. These findings may be of relevance for the future surgical decision-making in ACL reconstruction. Randomized controlled clinical trials comparing both fixation devices are desirable for the future.

[Robotics-mechanical bridge between imaging and patient]. / Robotik ­ maschinelle Brücke zwischen Bildgebung und Patient.

BACKGROUND: There are still a high number of dissatisfied knee arthroplasty patients. This situation has not changed much for decades, despite many innovations focusing on implant longevity and higher procedural precision. In this context, there is a growing discussion on possible systematic errors made in knee arthroplasty, especially regarding the alignment philosophy of the implants. OBJECTIVE: It was reported that a more anatomical alignment might result in improved patient outcome. However, current technologies have severe limitations to achieving optimized and individual alignment. In this context, the aim of this manuscript was to assess whether image-based robot-guided knee arthroplasty might represent an opportunity for achieving individualized alignment. METHODS: The literature on this subject was evaluated and analyzed. Furthermore, research projects and expert recommendations were discussed. RESULTS: The precision of preoperative planning is higher with robotic techniques than with other computer-assisted or manual technologies. In addition, the individual soft tissue situation of the patient is taken into account and the prosthesis position is optimized. This ensures optimum soft tissue balancing and stability of the prosthesis. CONCLUSION: Modern robot-assisted systems are the mechanical bridge between imaging and patient. This technique provides objective control over the results produced with alternative alignments. This applies to both the prosthesis position itself and the resulting soft tissue balancing.

Outcome of kinematic alignment using patient-specific instrumentation versus mechanical alignment in TKA: a meta-analysis and subgroup analysis of randomised trials.

INTRODUCTION: Kinematic alignment (KA) in total knee arthroplasty (TKA) matches component position to the pre-arthritic anatomy of an individual patient, with the aim of improving functional outcomes. Recent randomised controlled trials (RCTs) comparing KA to traditional neutral mechanical alignment (MA) have been mixed. This collaborative study combined raw data from RCTs, aiming to compare functional outcomes between KA using patient-specific instrumentation (PSI) and MA, and whether any patient subgroups may benefit more from KA technique. MATERIALS AND METHODS: A literature search in PubMed, EMBASE and Cochrane databases identified four randomised controlled trials comparing patients undergoing TKA using PSI-KA and MA. Unpublished data including Western Ontario McMaster Universities Arthritis Index (WOMAC) and Knee Society Score (KSS) were obtained from study authors. Meta-analysis compared MA to KA change (post-op minus pre-op) scores. Subgroup-analysis on KA patients looked for subgroups more likely to benefit from KA and the impact of PSI accuracy. RESULTS: Meta-analyses of change scores in 229 KA patients versus 229 MA patients were no different from WOMAC (mean difference 3.4; 95% confidence interval - 0.5 to 7.3), KSS function (1.3, - 3.9 to 6.4) or KSS combined (7.2, - 0.8 to 15.2). A small advantage was seen for KSS pain in the KA group (3.6, 95% CI 0.2-7.1). Subgroup-analysis showed no difference between varus, valgus and neutral pre-operative alignment groups, and those who did and did not achieve KA plans. Pain-free patients at 1-year were more likely to achieve KA plans. CONCLUSION: Patient-reported outcome scores following TKA using PSI-KA are similar to MA. No identifiable subgroups benefited more from KA, and long-term results remain unknown. Inaccuracy of the PSI system used in KA patients could potentially affect outcome.

Femoral interference screw fixation of hamstring and quadriceps tendons for ACL reconstruction.

PURPOSE: This cadaveric study compares the biomechanical properties of femoral graft fixation in ACL reconstruction of either quadriceps or hamstring tendon grafts with four different interference screws. The hypothesis was that quadriceps tendon grafts provide at least equal results concerning gap formation during cyclic loading and ultimate failure load compared to hamstring tendon grafts with four different interference screws. METHODS: Eighty porcine femora underwent interference screw fixation of human tendon grafts for ACL reconstruction. Either quadriceps (Q) or hamstring (H) tendon grafts and four different bioabsorbable interference (Wolf (W), Storz (S), Mitek (M), Arthrex (A)) screws were used, resulting in 8 groups with 10 specimens per groups (WQ, WH, SQ, SH, MQ, MH, AQ, AH). Biomechanical analysis included pretensioning the constructs with 60 N for 30 s, then cyclic loading of 500 cycles between 60 and 250 N at 1 Hz in a servohydraulic testing machine, with measurement of elongation and stiffness including video measurements. After this, ultimate failure load and failure mode analysis were performed. RESULTS: No statistically significant difference could be noted between the groups regarding gap formation during cyclic loading [Cycles 21-500 (mm): WQ 3.6 ± 0.8, WH 3.9 ± 1.4, SQ 3.6 ± 0.8, SH 3.3 ± 1.5, MQ 4.3 ± 0.8, MH 4.6 ± 1.0, AQ 4.8 ± 0.8, AH 4.3 ± 1.5, n.s.], stiffness during cyclic loading [Cycles 21-500 (N/mm): WQ 72.9 ± 16.9, WH 71.6 ± 20.7, SQ 69.5 ± 23.9, SH 77.4 ± 25.1, MQ 59.6 ± 11.2, MH 48.4 ± 15.4, AQ 48.8 ± 12.7, AH 51.9 ± 22.2, n.s.], and ultimate failure load [(N): WQ 474.4 ± 88.0, WH 579.3 ± 124.2, SQ 493.9 ± 105.2, SH 576.0 ± 90.4, MQ 478.6 ± 59.0, MH 543.9 ± 119.7, AQ 480.2 ± 93.8, AH 497.8 ± 74.2, n.s.]. CONCLUSIONS: Quadriceps tendon grafts yield comparable biomechanical results for femoral interference screw fixation in ACL reconstruction compared to hamstring tendon grafts. From a clinical perspective, quadriceps tendon grafts should therefore be considered as a good option in ACL reconstruction in the future.

[Custom-fit kinematic alignment in total knee arthroplasty using PSI. The story of ShapeMatch technology]. / Patientenindividuelle kinematische Prothesenausrichtung per Schnittblocktechnik. Die Chronik der ShapeMatch-Technologie.

BACKGROUND: The story of ShapeMatch® custom-fit cutting guides for primary total knee arthroplasty (TKA) is special compared to other available techniques. First, it was the first such patient-specific instrument (PSI) on the market. Second, the underlying philosophy of kinematic alignment is unique compared to other competitors. Finally, it is the only PSI technique that has been withdrawn from the market. OBJECTIVES AND METHODS: The objective of this paper is to summarize the history of the ShapeMatch® technology and to review the current literature regarding clinical evidence for kinematically aligned TKA. RESULTS AND CONCLUSIONS: In the recent literature, faster rehabilitation, better knee function and higher patient satisfaction are described for kinematically aligned TKA compared to conventional alignment. However, there is also evidence for inaccuracies by using the PSI technology as a possible cause of treatment failures. Due to those problems, this technology was recalled from the market. As an alternative method to achieve kinematic alignment in TKA, manual as well as computer-assisted techniques are currently under development and are discussed here.

[Kinematic alignment in total knee arthroplasty : Concept, evidence base and limitations]. / Kinematisches Alignment in der Knieendoprothetik : Konzept, Evidence und Limitation.

BACKGROUND: Against the background that 20 % of patients are dissatisfied after total knee arthroplasty, there is ongoing controversy about optimal alignment. In this context, orientating the prosthetic components to the natural kinematic axes of the knee appears to be an interesting new concept. METHODS: The objective of this paper is to provide a critical review of the current literature and our own research data regarding the concept of kinematically aligned total knee arthroplasty with the current evidence base and potential limitations. RESULTS AND DISCUSSION: In the recent literature faster rehabilitation, better knee function, and higher patient satisfaction are described compared to conventional alignment, even if the postoperative alignment deviates more than 3° from the mechanical axis. However, the technique may not be suitable for every patient and pathology, and further research is necessary to set the correct indication.

[Alloarthroplasty versus above-knee amputation]. / Alloarthroplastik kontra transfemorale Amputation.

BACKGROUND: We report an unusual case of a 38-year-old physically active patient, who suffered a Ewing sarcoma during adolescence and was therefore treated with a tumor endoprostheses ex domo (replacement of distal femur and proximal tibia). Since then he had undergone a couple of surgical interventions for revision and is currently suffering from persistent pain in the leg concerned. An aseptic loosening of the tibial component was evident after radiologic examinations. Because he had suffered for so long our patient refused further surgery to retain the affected limb and he preferred amputation. OBJECTIVES: We would have taken the risk of a femoral residual limb that is much too short compared with a classical above-knee amputation. In this regard we saw difficulties in exoprosthetic treatment with functional limitations that could easily have influenced the outcome negatively. METHOD: Consequently, we decoupled the tibial component from the femoral one within the knee joint and thus performed a knee disarticulation leaving the femoral component. RESULTS: Postoperatively, we found a mostly harmonious gait pattern with a pure mechanical interim prosthesis regarding time-distance parameters, which may be even further improved with the final prosthesis. Sagittal joint angles are comparable to conventionally knee exarticulated ones. DISCUSSION: To date, no comparable case of such an alloarthroplasty, which could regain mobility with an exoprosthetic treatment has been highlighted in the literature. In the result, a knee disarticulation within the area of a knee arthroplasty leaving the femoral component is not inferior to"ordinary" knee disarticulation.

[Patella in Place Balancer: Technique for total knee arthroplasty]. / Patella-in-Place-Balancing : Technik für die Knieprothetik.

BACKGROUND: The gap-balancing technique is well established in primary total knee arthroplasty to determine femoral rotation and flexion gap stability. However, it has been reported that the everted or luxated extensor mechanism during this procedure in addition to soft tissue releases performed may cause inaccurate flexion-gap determination and thus result in malpositioning of the femur or instability. In this article the alternative technique of a Patella in Place Balancer (PIPB) with a no tissue release philosophy is introduced. METHOD: In this procedure, at first, the tibia resection is performed and a tibia baseplate inserted. Then, two pins are drilled into the sagittal profile of the femoral condyles. After anatomical repositioning of the extensor apparatus the pins are screwed in until the flexion gap is spanned. In this position femoral component orientation is determined parallel to the tibia. We describe the current clinical experience based on a retrospective review of 3,000 patients. Moreover, initial results of a prospective study are outlined. RESULTS: The PIPB technique was suitable for the treatment of primary and secondary gonarthrosis if the collateral ligaments were intact. The detected revision rate was about 1.21 %. Only 2 % of the treated patients reported back with an unsatisfactory outcome 1 year after surgery. In the prospective survey of 33 patients a significant improvement in the KOOS Score could be documented (29.3 points preoperatively vs. 63.5 postoperatively (p < 0.05)). DISCUSSION: The PIPB overcomes the major limitation of the gap balancing technique with regard to the inaccuracy caused by the dislocated extensor mechanism. After a learning curve, the technique appears to be safe and reliable. Preliminary data show promising results.

[Skin and soft tissue complications after orthopedic interventions on tumors : interdisciplinary management]. / Haut- und Weichteilkomplikationen nach tumororthopädischen Eingriffen : Interdisziplinäres Management.

Interdisciplinary collaboration between orthopedic and plastic surgeons is indicated in reconstructive surgery of the extremities for both traumatic orthopedic fractures with extensive soft tissue damage and musculoskeletal tumor resection. We want to emphasize the need for close cooperation starting in the preoperative planning for reconstruction after tumor resection in order to discuss and establish a unified approach. This is particularly important to establish a joint approach with special consideration of possibly necessary adjuvant therapies. One collaborative approach is for the orthopedic surgeon to resect the tumor and the plastic surgeon to carry out the defect reconstruction for exclusive soft tissue coverage including flap surgery as well as for functional reconstruction depending on the location and extent of tumor resection. Thus, careful preoperative and postoperative communication on the precise location, extent of tumor resection and the therapy timing between the orthopedic surgeon and the plastic surgeon will allow the most effective subsequent repair of the resection site.

Suture anchor repair yields better biomechanical properties than transosseous sutures in ruptured quadriceps tendons.

PURPOSE: This human cadaveric study compares the biomechanical properties of quadriceps tendon repair with suture anchors and the commonly applied transosseous sutures. The hypothesis was that suture anchors provide at least equal results concerning gap formation and ultimate failure load compared with transosseous suture repair. METHODS: Thirty human cadaveric knees underwent tenotomy followed by repair with either 5.5-mm-double-loaded suture anchors [titanium (TA) vs. resorbable hydroxyapatite (HA)] or transpatellar suture tunnels using No. 2 Ultrabraid™ and the Krackow whipstitch. Biomechanical analysis included pretensioning the constructs with 20 N for 30 s and then cyclic loading of 250 cycles between 20 and 100 N at 1 Hz in a servohydraulic testing machine with measurement of elongation. Ultimate failure load analysis and failure mode analysis were performed subsequently. RESULTS: Tendon repairs with suture anchors yielded significantly less gap formation during cyclic loading (20th-250th cycle: TA 1.9 ± 0.1, HA 1.5 ± 0.5, TS 33.3 ± 1.9 mm, p < 0.05) and resisted significantly higher ultimate failure loads (TA 740 ± 204 N, HA 572 ± 67 N, TS 338 ± 60 N, p < 0.05) compared with transosseous sutures. Common failure mode was pull-out of the eyelet within the suture anchor in the HA group and rupture of the suture in the TA and TS group. CONCLUSION: Quadriceps tendon repair with suture anchors yields significantly better biomechanical results than the commonly applied transosseous sutures in this human cadaveric study. These biomechanical findings may change the future clinical treatment for quadriceps tendon ruptures. Randomised controlled clinical trials are desirable for the future. LEVEL OF EVIDENCE: Not applicable, controlled laboratory human cadaveric study.

[Computer-assisted systems in total knee arthroplasty. Useful aid or only additional costs]. / Computerassistenzsysteme in der Knieendoprothetik. Sinnvolle Hilfsmittel oder nur Mehraufwand.

BACKGROUND: The primary goal of computer-assisted surgery (CAS) in total knee arthroplasty is to increase the accuracy in terms of prosthesis positioning. In theory, this would lead to longer implant survival and a reduction of malpositioning. Thus, a better clinical outcome and lower revision rates would be expected. However, the necessary technical equipment represents significant additional effort and cost factors which are not included in the current diagnosis-related groups (DRG) system. OBJECTIVE: The objective of this article is a critical review of the current literature to examine whether these costs are reasonable by taking the additional benefits of the technology into account. METHODS: This review is based on a selective PubMed search on CAS and navigation in primary total knee arthroplasty. RESULTS: The current evidence base on CAS suggests that at least the primary outcome parameter, the improvement of the radiological alignment, is achieved by the technique. However, the claimed secondary effects are not yet proven. In particular, an improvement of clinical outcome and patient satisfaction has not been demonstrated so far. Furthermore, there is some evidence of increased complication rates by the use of CAS. CONCLUSION: Against this background and with respect to further cost-benefit analyses, the technology has to be reviewed critically. In particular, low-volume units do not seem to benefit from the use of CAS. However, the assessment of long-term effects is still pending.

CCD and offset after Nanos short stem in total hip arthroplasty.

BACKGROUND: Many short stems for total hip arthroplasty have been introduced by the manufacturers only during the last decade. One of them is the Nanos short stem (Smith and Nephew, Marl, Germany). The development of short stems was aimed at preserving bone and soft tissue by utilizing a minimally invasive approach, thus allowing a quick return to an active life. It was purpose of this study to evaluate the radiological changes after using this device. METHODS: We present the radiological results of 202 cementless THAs which were performed in 172 patients using the Nanos stem. Radiological evaluation was performed using standing anterior-posterior (AP) and lateral radiographs of the proximal femur preoperatively, postoperatively and during the follow up. We analyzed the preoperative and postoperativ CCD angle, the subsisdence, preoperative and postoperative offset, osteolysis, bone resorption, increased density, neocortex and periarthricular ossifications. RESULTS: One stem had to be revised due to subsidence four days after implantation. Two cups (BiconPlus, Smith and Nephew, Marl, Germany) had to be revised during the time of follow up due to an aseptic cup loosening. Two stems showed radiolucent lines at the implant-bone-interface at the last follow-up. An increase of bone density could be detected in 18 hips (8.9%). 14 hips showed periarticular ossifications. Measurable subsidence was detected in a total of four stems (1.9%). The preoperative neck-shaft-angle angle was 133.8 ± 4.4° (range: 118.5-146.2) and the neck-shaft-angle angle at the time of follow up was 134.6 ± 4.3° (range: 123.3-147; P< 0.05). The preoperative and postoperative offset changed from 109.3 ± 11.9 mm (range: 80.9-131.6) to 109.7 ± 12.3 mm (range: 79.7-155.6; P< 0.05). CONCLUSION: In summary, this study shows that a correct anatomical reconstruction is possible with a device of this design. The outcome is comparable to that of other short stems. Further studies should be performed in a prospective and randomized design to evaluate the advantage of such a device with a higher level of evidence.

The influence of a single-radius-design on the knee stability.

Prostheses with single radius (SR) design were supposed to be as good as the physiological kinematic and stability of the knee. This in-vitro biomechanical study compared SR to a multiple radius (MR) design on the one hand and seven left human knee specimens were used. The SR and MR knee prosthesis where implanted with a navigation system. We measured varus/valgus deviation of the mechanical axis and the deviation of the joint-line to the epicondyle-line in different knee flexion degrees (0°, 30°, 45°, 60° and 90°) with and without 15 Nm of varus and valgus stress. Without varus/valgus-stress in all three groups (physiological knee, SR and MR prosthesis) the results were located on the varus-site. The variation of the SR was less than the MR, without being significant. Under varus and valgus stress varus/valgus axis deviation constantly grew. From 0-60° no significant deviation between the two prosthesis models was found. At 90° flexion varus/valgus deviation with the SR component was significantly (p ⩽ 0.05) smaller compared to the MR design. This in-vitro study showed that the SR prosthesis is significantly more stable in the coronal plane than the MR in higher flexion degrees. This could have an improved effect on biomechanical stability with a higher clinical function after SR-TKA.

Development and clinical validation of an unobtrusive ambulatory knee function monitoring system with inertial 9DoF sensors.

Patients suffering from end-stage knee osteoarthritis are often treated with total knee arthroplasty, improving their functional mobility. A number of patients, however, report continued difficulty with stair ascent and descent or sportive activity after surgery and are not completely satisfied with the outcome. State-of-the-art analyses to evaluate the outcome and mobility after knee replacement are conducted under supervised settings in specialized gait labs and thus can only reflect a short period of time. A number of external factors may lead to artificial gait patterns in patients. Moreover, clinically relevant situations are difficult to simulate in a stationary gait lab. In contrast to this, inertial sensors may be used additionally for unobtrusive gait monitoring. However, recent notable approaches found in literature concerning knee function analysis have so far not been applied in a clinical context and have therefore not yet been validated in a clinical setting. The aim of this paper is to present a system for unsupervised long-term monitoring of human gait with a focus on knee joint function, which is applicable in patients' everyday lives and to report on the validation of this system gathered during walking with reference to state-of-the-art gait lab data using a vision system (VICON Motion System). The system KINEMATICWEAR - developed in close collaboration of computer scientists and physicians performing knee arthroplasty - consists of two sensor nodes with combined tri-axial accelerometer, gyroscope and magnetometer to be worn under normal trousers. Reliability of the system is shown in the results. An overall correlation of 0.99 (with an overall RMSE of 2.72) compared to the state-of-the-art reference system indicates a sound quality and a high degree of correspondence. KINEMATICWEAR enables ambulatory, unconstrained measurements of knee function outside a supervised lab inspection.

[Biodegradable synthetic implant materials : clinical applications and immunological aspects]. / Degradable synthetische Implantatmaterialien : Klinische Applikationen und immunologische Aspekte.

In the last decade biodegradable synthetic implant materials have been established for various clinical applications. Ceramic materials such as calcium phosphate, bioglass and polymers are now routinely used as degradable implants in the clinical practice. Additionally these materials are now also used as coating materials or as microspheres for controlled drug release and belong to a series of examples for applications as scaffolds for tissue engineering. Because immense local concentrations of degradation products are produced during biodegradation, this review deals with the question whether allergic immune reactions, which have been reported for classical metallic and organic implant materials, also play a role in the clinical routine for synthetic biodegradable materials. Furthermore, possible explanatory theories will be developed to clarify the lack of clinical reports on allergy or sensitization to biodegradable synthetic materials.