RESUMEN
This paper continues the previous investigation of the Department on the lymphoid tissue of central and peripheral lymphoid organs under different experimental conditions. The morphological reactional modalities of the intestinal lymphoid tissue in the male Wistar rat were followed up under endocrine imbalance conditions following cortisone administration. Seven days after administration cortisone induced a hyperplasia of the intestinal lymphoid tissue in parallel with a depletion of the lymph node parenchyma and a hypercellularity of bone marrow. After a 6-week postcortisone interval, the lymphoid tissue showed changes corresponding to a cellular depletion in parallel with the restoration of the lymph node parenchyma and a normocellular bone marrow.
Asunto(s)
Cortisona/farmacología , Intestino Delgado/efectos de los fármacos , Tejido Linfoide/efectos de los fármacos , Animales , Médula Ósea/efectos de los fármacos , Células de la Médula Ósea , Intestino Delgado/citología , Tejido Linfoide/citología , Masculino , Ratas , Ratas Endogámicas , Factores de TiempoRESUMEN
Bilateral ovariectomy of Wistar rats has per se a stimulative effect on the myeloid tissue, determining a hypercellularity of this organ-tissue. On the other hand, under the conditions of a whole-body irradiation with a single dose of 800 r X-rays, bilateral ovariectomy manifests a protective effect on the myeloid tissue preventing the development of hypoplastic, respectively aplastic modifications.
Asunto(s)
Médula Ósea/efectos de la radiación , Castración , Tejido Adiposo/anatomía & histología , Animales , Células de la Médula Ósea , Eritrocitos/citología , Femenino , Granulocitos/citología , Células Madre Hematopoyéticas/citología , Linfocitos/citología , Megacariocitos/citología , Ratas , Ratas EndogámicasRESUMEN
Cortisone administration in male Wistar rat induces a depletion of the granulocytic-normoblastic cell population in the bone marrow in parallel with a numerical increase by accumulation of lymphoid and undifferentiated cells. These changes are more intense under irradiation conditions. The reversibility of medullary modifications is shown by the integrity of the reticulinic skeleton of the bone marrow.
Asunto(s)
Médula Ósea/efectos de los fármacos , Médula Ósea/efectos de la radiación , Cortisona/efectos adversos , Animales , Ganglios Linfáticos/efectos de los fármacos , Ganglios Linfáticos/efectos de la radiación , Masculino , Ratas , Bazo/efectos de los fármacos , Bazo/efectos de la radiaciónRESUMEN
The postnatal development of the three major salivary glands (parotid, submaxillary and sublingual) was comparatively followed up from the histological viewpoint and in relation with some histochemical reactions. The sublingual gland presented a well developed cytomorphological structure at birth, whereas the parotid and the submaxillary ones, immature at birth, gradually reached the overall appearance of adult glands, the former at 5--6 weeks, the latter at 8 weeks. In relation with the product secreted, it is already from birth that the parotid and the submaxillary glands presented negative reactions for mucosubstances and positive ones for revealing the protein-bound groups. The sublingual gland exhibited from the first postnatal 24 hrs positive reactions for revealing mucosubstances at the level of glandular secretory glands.
Asunto(s)
Animales Recién Nacidos/crecimiento & desarrollo , Glándulas Salivales/anatomía & histología , Glándulas Salivales/citología , Glándulas Salivales/metabolismo , Factores de Edad , Animales , Glándula Parótida/citología , Ratas , Glándulas Salivales/crecimiento & desarrollo , Glándula Sublingual/citología , Glándula SubmandibularRESUMEN
The whole-body irradiation of adult Wistar rats with a single dose of 800 r X-rays intensifies the lymph node changes and the decrease of the colloidopexic capacity of hepatosplenic macrophages established by the "reverse" administration of sexual hormones. The modifications observed after estradiol administration to the male rat are more marked after a 6 months' interval than those caused in the same interval by testosterone in the female rat lymph nodes.
Asunto(s)
Estradiol/farmacología , Ganglios Linfáticos/efectos de los fármacos , Efectos de la Radiación , Testosterona/farmacología , Animales , Femenino , Ganglios Linfáticos/efectos de la radiación , Masculino , Ratas , Factores Sexuales , Rayos XRESUMEN
The authors have studied the effect of testosterone administration in male adult Wistar rats irradiated with a single total dose of 800 r X-rays. The results obtained show that testosterone exerts a double radioprotective action. This hormone prevents both the occurrence of the senile type spleen and lymph node changes and the depression of the colloidopexic capacity of the hepatosplenic macrophages. At the same time, these results suggest that testosterone induces hyperplasia of the lymphocytic elements, particularly of T lymphocytes.
Asunto(s)
Ganglios Linfáticos/metabolismo , Bazo/metabolismo , Testosterona/farmacología , Envejecimiento , Animales , Hiperplasia/patología , Ganglios Linfáticos/patología , Macrófagos/patología , Masculino , Quimera por Radiación , Ratas , Bazo/patologíaAsunto(s)
Hiperlipidemias/inducido químicamente , Lípidos/sangre , Parasimpaticomiméticos/farmacología , Polietilenglicoles , Simpatomiméticos/farmacología , Animales , Colesterol/sangre , Ácidos Grasos no Esterificados/sangre , Hiperlipidemias/metabolismo , Metabolismo de los Lípidos , Ratas , Triglicéridos/sangreRESUMEN
The effects of the X-rays on the peripherial lymphoid organs (lymph nodes and spleen) in male adult wistar rats "chemically thyroidectomized" (methylthiouracil) have been studied. Spontaneous death of these animals 9 days after the irradiation was determined by the hypoplasia (aplasia) of the hematogenous bone marrow. The spleen and lymph node changes -- represented by the lymphoid tissue depletion and reticulofibrosis -- in the experimental animals were similar to those observed in animals sacrificed 6-8 months after irradiation. They differed from the latter by the absence of the macromolecular hyperstability of the reticular and collagenous fibers, which is proper to early ageing by X-rays.