Asunto(s)
Anomalías Múltiples/inmunología , Desensibilización Inmunológica/métodos , Diarrea/inmunología , Enterocolitis/inmunología , Hipersensibilidad a los Alimentos/inmunología , Vómitos/inmunología , Alérgenos/efectos adversos , Alérgenos/inmunología , Animales , Bovinos , Niño , Preescolar , Culinaria , Calor/efectos adversos , Humanos , Inmunoglobulina E/inmunología , Lactante , Proteínas de la Leche/efectos adversos , Proteínas de la Leche/inmunología , SíndromeRESUMEN
BACKGROUND AND AIMS: Our study evaluated the prevalence, the characteristics and implications of the upper gastrointestinal localisation (UGI+) in paediatric Crohn's Disease (CD) patients. METHODS: This prospective study evaluated 45 newly diagnosed CD patients at diagnosis and follow up with respect to CD localisation. RESULTS: All patients presented CD at the colon and/or ileum. In 24/45 patients (53.3%, 12 F and 12 M) an UGI+ involvement was also found. UGI+ patients had a younger age of onset (10.9 years versus 12.6 years; P<0.05). PCDAI at diagnosis was significantly higher in the UGI+ (41 vs. 25 P<0.01). UGI+ patients were overall more symptomatic. Pancolitis and extraintestinal manifestations were also more frequent (19/24 (80%) vs. 12/21 (57%) P<0.01). Growth was more impaired at diagnosis in UGI+ patients. By the end of the follow-up (mean 3 years, range 2 to 4) no significant difference was found in PCDAI (17 in UGI+ patients vs. 11 in UGI- P=NS), or the number of relapses. Weight and growth catch-up in UGI+ patients were comparable to UGI- ones. However, UGI+ patients required a more aggressive therapeutic approach. CONCLUSION: At least half of paediatric onset CD patients have an upper gastrointestinal localisation. UGI+ patients present an earlier onset and a more severe disease. The final outcome does not differ, but UGI+ patients require a more aggressive therapeutic approach.
Asunto(s)
Enfermedad de Crohn/patología , Tracto Gastrointestinal Superior/patología , Adolescente , Edad de Inicio , Niño , Enfermedad de Crohn/diagnóstico , Enfermedad de Crohn/epidemiología , Femenino , Humanos , Masculino , Estudios ProspectivosAsunto(s)
Política de Salud , Hipertensión/terapia , Salud Pública/tendencias , Dieta Hiposódica/tendencias , Femenino , Análisis de los Alimentos , Humanos , Hipertensión/etiología , Masculino , Obesidad/complicaciones , Obesidad/prevención & control , Sodio/administración & dosificación , Sodio/análisis , Estados UnidosRESUMEN
Recommendations for dietary sodium reduction can be communicated effectively when the role of sodium in food processes is understood, Knowledge of why sodium is present in foods helps the dietitian to predict likely and unlike sodium sources. When this information is used in counseling, dietary modifications may become less complex because they are based on knowledge and understanding, not on the memory of long lists of individual foods. Examining the role of sodium in food production practices can assist the knowledge-understanding-counseling effort.