RESUMEN
Treatment of pregnant rats with ursodeoxycholic acid or chenodeoxycholic acid at 3 dose levels resulted in no dismorphogenic effects although embryotoxicity and fatty infiltration in maternal liver were more frequent after CDCA. Light microscopic examination showed no evidence of derangement in fetal liver. Electron microscopic study, carried out in maternal liver, showed that changes were present only in dams treated with the highest doses of both bile acids.
Asunto(s)
Ácido Quenodesoxicólico/toxicidad , Ácido Desoxicólico/análogos & derivados , Embrión de Mamíferos/efectos de los fármacos , Preñez/efectos de los fármacos , Ácido Ursodesoxicólico/toxicidad , Animales , Femenino , Muerte Fetal/inducido químicamente , Hígado/patología , Masculino , Embarazo , RatasAsunto(s)
Compuestos Bicíclicos con Puentes/uso terapéutico , Hidrocarburos Aromáticos con Puentes/uso terapéutico , Enfermedades Funcionales del Colon/tratamiento farmacológico , Ácidos Ciclohexanocarboxílicos , Endoscopía , Parasimpatolíticos/uso terapéutico , Adulto , Anciano , Enfermedades Funcionales del Colon/diagnóstico , Endoscopía/efectos adversos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Náusea/tratamiento farmacológico , Vómitos/tratamiento farmacológicoAsunto(s)
Ácidos y Sales Biliares/sangre , Hepatopatías/diagnóstico , Adolescente , Adulto , Anciano , Enfermedad Crónica , Pruebas Enzimáticas Clínicas , Femenino , Hepatitis/sangre , Hepatitis/diagnóstico , Humanos , Cirrosis Hepática/sangre , Cirrosis Hepática/diagnóstico , Hepatopatías/sangre , Pruebas de Función Hepática , Masculino , Persona de Mediana EdadRESUMEN
A functional study was made of 40 patients with bioptically diagnosed CPH. Fractional BSF clearance was the most frequently altered test and its correlation with the anatomical damage was significant. In particular, the fractional uptake clearance (K1) gave a pointer to both the presence of liver damage and its type. Elimination clearance (K2) may also be useful, especially in the differentiation of histological pictures on the borderline between CAH and CPH. In the evaluation of CPH, therefore, BSF clearance is of marked assistance both in rounding out the histological diagnosis, and in cutting down the need for control biopsies.