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Bioorg Med Chem Lett
; 14(19): 4847-50, 2004 Oct 04.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15341937
RESUMEN
A series of N-(1-benzylpyrrolidin-3-yl)arylbenzamides 8 has been prepared, and their structure-activity relationships studied. Potent ligands selective for human D(4) (hD(4)) over hD(2) and alpha(1) have been identified. One example was determined to be an antagonist in a cAMP assay, with an IC(50) of 1500 nM.