Mucosal mast cells are indispensable for the timely termination of Strongyloides ratti infection.

Mast cells and basophils are innate immune cells with overlapping functions that contribute to anti-helminth immunity. Mast cell function during helminth infection was previously studied using mast cell-deficient Kit-mutant mice that display additional mast cell-unrelated immune deficiencies. Here, we use mice that lack basophils or mucosal and connective tissue mast cells in a Kit-independent manner to re-evaluate the impact of each cell type during helminth infection. Neither mast cells nor basophils participated in the immune response to tissue-migrating Strongyloides ratti third-stage larvae, but both cell types contributed to the early expulsion of parasitic adults from the intestine. The termination of S. ratti infection required the presence of mucosal mast cells: Cpa3Cre mice, which lack mucosal and connective tissue mast cells, remained infected for more than 150 days. Mcpt5Cre R-DTA mice, which lack connective tissue mast cells only, and basophil-deficient Mcpt8Cre mice terminated the infection after 1 month with wild-type kinetics despite their initial increase in intestinal parasite burden. Because Cpa3Cre mice showed intact Th2 polarization and efficiently developed protective immunity after vaccination, we hypothesize that mucosal mast cells are non-redundant terminal effector cells in the intestinal epithelium that execute anti-helminth immunity but do not orchestrate it.

[Evaluation of a collaborative goal setting intervention in patients with chronic back pain]. / Evaluation einer Intervention zur partizipativen Vereinbarung von Rehabilitationszielen bei Patienten mit chronischen Rückenschmerzen.

BACKGROUND AND OBJECTIVE: Although setting rehabilitation goals is considered to be a core rehabilitation process, in actual rehabilitation practice there is a considerable need for improvement with respect to consistent goal orientation. The objective of the PARZIVAR project was therefore to develop an intervention for participative goal setting in medical rehabilitation. This article reports the results of the evaluation of the PARZIVAR intervention in patients with chronic back pain. METHODS: The PARZIVAR intervention was evaluated in a sequential control group design with 3 measurement points (before the start of rehabilitation, at the end of rehabilitation, and at 6-month follow-up). The proximal endpoints were defined as patient perception of participative goal setting, subjective awareness of goals, and satisfaction with goal setting. The distal endpoints were intensity of pain and generic and illness-specific functioning. RESULTS: Overall, the degree of achieving aspects of participative goal setting was higher in the intervention group. There were no differences regarding satisfaction with goal setting, however, and distal outcomes also remained unchanged after the intervention was implemented. DISCUSSION: Participation in the PARZIVAR intervention was partially reflected in the perception of the rehabilitation patients, but the effects regarding distal outcomes in the intervention group did not exceed those of usual care. There is a need for more research into how concepts of goal setting can be improved in the future to better address the diverse functions of goal setting.

[Goal setting in inpatient medical rehabilitation: exploring the current practice]. / Reha-Zielvereinbarungen - gegenwärtige Praxis in der stationären medizinischen Rehabilitation.

OBJECTIVE: Goal setting is regarded as a key element in the rehabilitation process. Information about current goal setting practice is limited. However, there is potential for further improvement, e. g. as far as patient participation in the goal setting process is concerned. The study reports results of a survey on the current practice of goal setting in medical rehabilitation, focusing on development potential. The study examines acceptance and requirements for goal setting as well as patients' and professionals' experiences regarding goal setting during the rehabilitation process, with an emphasis on patient participation. METHODS: A total of n=40 rehabilitation professionals and n=210 inpatients with a diagnosis of chronic back pain, diabetes mellitus type 2 or coronary heart disease were surveyed at six rehabilitation centres using a questionnaire. Questionnaires contained predominantly closed-ended items regarding the current practice of goal setting. Several items were identical for both groups. In addition to the quantitative evaluation by means of frequency analyses free text data were evaluated. RESULTS: Rehabilitation professionals saw various benefits in goal setting with patients. Many professionals experienced patients to have personal goals for their rehabilitation, and most of them believed that patient participation in goal setting is possible. Also, barriers and requirements for goal setting were identified. A consistent concept for goal setting, involvement of and exchange between the different occupational groups and an elaborate handling of information in the context of goal setting seem to be realised at least partially. Professionals and patients reported similar frequencies of talks on goal setting at different times during the rehabilitation course. Patient participation seems to be realised to some extent but not comprehensively. The results show slight discrepancies between patients' and professionals' statements. DISCUSSION: Current practice of goal setting in inpatient rehabilitation of patients with the diagnoses named above is altogether on a relatively advanced level in the rehabilitation centres taking part in the study. The study identifies potential for development concerning a comprehensive implementation of goal setting, the realisation of patient participation, goal documentation and their integration into rehabilitation. Moreover, deeper involvement of the rehabilitation team and a stronger conceptual integration of the subject within the centres seem desirable. This can be taken up within the scope of interventions.

[Quality assurance in outpatient medical rehabilitation - concept and results of a pilot project to develop a quality assurance programme for musculoskeletal and cardiac diseases]. / Qualitätssicherung in der ambulanten medizinischen Rehabilitation: Konzeption und Ergebnisse eines Pilotprojekts zur Entwicklung eines Qualitätssicherungsprogramms für die Indikationsbereiche muskuloskeletale und kardiologische Erkrankungen.

PURPOSE: The concept and results of a pilot project to develop a quality assurance programme for outpatient medical rehabilitation in musculoskeletal and cardiac diseases are discussed. The processes developed and the results that were achieved using the instruments in 24 pilot institutions are described. METHODS: The quality of structure was assessed by defining and applying basic and detailed criteria; a version of peer review for outpatient treatment was developed to test the quality of process. The quality of results was determined by means of a prospective study with two or three measurement times and implementation of generic and disease-specific measurement instruments. The process was tested on n=1475 patients with musculoskeletal diseases and n=843 patients with cardiac diseases. RESULTS: The level of the quality of structure in the participating centres is quite high; 89-93% of the structure features required were fulfilled. The peer review indicated that the process had 25-40% serious shortcomings in cardiology and 15-20% for musculoskeletal diseases. The quality of results measurements show that the participating outpatient rehab centres achieved medium effects for the majority of the core rehab dimensions for the respective indications, but the findings also showed that at the time the follow-up reports were made there was often a reduction of positive effects and high effects were quite rare. While there were marked differences in quality of structure and process among the various institutions, there were only slight differences among the outpatient centres regarding quality of results. CONCLUSIONS: A scientifically sound quality assurance programme was developed that covers specific aspects of outpatient rehabilitation, to a great extent using the same structures that have been implemented in the quality assurance programmes for inpatient treatment. To implement the results presented here, the scientific findings will need to be evaluated in the respective committees of the cost-carriers. The tests of the programme in 24 pilot institutions showed an overall high level of quality, but also revealed potential for improvement in some areas.

[The only child in pediatric neuropsychiatric patient material]. / Das Einzelkind im kinderneuropsychiatrischen Krankengut

In the older literature, single children were usually considered as being subject to particularly pathogenetic situations. In the more recent literature, on the other hand, the emphasis has usually been on psychoreactive disorders of single children. The author and his associates have been able to show that in a comparison of single children and multiple children different socioeconomic conditions are of major importance and tend to play a decisive role in the complex pathogenetic structure of certain diseases. Therefore, it is necessary that, so fat as the prevention of diseases that we are concerned here with is concerned, far more attention be given to children in multiple-children families (inasmuch as three-children families are required for an adequate reproduction of our society, a fact which has been convincingly demonstrated by Mehlan in 1963).