1.
Org Lett
; 22(23): 9169-9173, 2020 12 04.
Artículo
en Inglés
| MEDLINE
| ID: mdl-33186036
RESUMEN
We report herein the Pd-catalyzed oxazoline-directed C-H olefination of the N-arylindole skeleton, affording two diastereomers of axially chiral olefin-oxazoline ligands in a one-step procedure. Modifications at the 3- and 3'-positions were facilely achieved via electrophilic substitution of the indole fragment and subsequent oxazoline-directed C-H amidation or olefination of the arene fragment.