1.
Bioorg Med Chem Lett
; 19(2): 328-31, 2009 Jan 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19091559
RESUMEN
Ortho-biphenyl carboxamides, originally prepared as inhibitors of microsomal triglyceride transfer protein (MTP) have been identified as novel inhibitors of the Hedgehog signaling pathway. Structure-activity relationship studies for this class of compounds reduced MTP inhibitory activity and led to low nanomolar Hedgehog inhibitors. Binding assays revealed that the compounds act as antagonists of Smoothened and show cross-reactivity for both the human and mouse receptor.