Transarterial aortic valve replacement with a self expanding stent in pigs.

OBJECTIVES: To evaluate the feasibility of percutaneous aortic valve replacement without cardiac arrest in animal experiments. METHODS: A self expanding nitinol stent, containing pulmonary valves from pigs in its proximal part, was implanted in six pigs (94-118 kg) by means of a 25 French catheter through the left subclavian artery under guidance of fluoroscopy and transoesophageal echocardiography. During stent deployment the original aortic valve was pushed against the aortic wall by the self expanding force of the stent while the new valve was expanded. RESULTS: It was possible to replace the aortic valve in the beating heart in four pigs (67%) with no complication or relevant drop in blood pressure. The procedure failed in two pigs (33%) due to dysfunction of the catheter device in one case and to problems with correct positioning in the left ventricular outflow tract in the other. After successful stent valve implantation, dopamine was infused in doses of 5 microg/kg/min, 10 microg/kg/min, and 15 microg/kg/min. Cardiac output increased from 4.4 to 8.8 l/min and the mean arterial pressure rose from 79 to 105 mm Hg. The maximum peak to peak pressure gradient across the valve carrying stent reached a maximum of 8 mm Hg under dopamine infusion. All pigs were killed six hours after transvascular aortic valve replacement. The chest was opened, and the left ventricle and the ascending aorta were carefully inspected. There were no signs of malfunction of the implant, of damage of the aortic vessel wall, or of obstruction of the coronary ostia. CONCLUSIONS: Percutaneous aortic valve replacement with a self expanding nitinol stent in the beating heart is possible. The device was safe under pharmacological stress test. After successful chronic animal experiments, this concept may become a feasible option for treating patients with relevant aortic valve disease but where open heart surgery would be risky.

Thermo-optical properties of air-clad photonic crystal fiber lasers in high power operation.

We report on the investigation of the thermo-optical behavior of air-clad ytterbium-doped large-mode-area photonic crystal fiber lasers. Analytical and numerical models are applied to calculate the heat distribution and induced stresses in a microstructured fiber. The results are compared to conventional double-clad fiber lasers and design guidelines are provided to ensure maximum heat dissipation and scalability to power levels of several kWs.