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1.
Mouse IL-2/CD25 Fusion Protein Induces Regulatory T Cell Expansion and Immune Suppression in Preclinical Models of Systemic Lupus Erythematosus.
J Immunol;
207(1): 34-43, 2021 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34108258
2.
Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).
J Med Chem;
62(20): 8953-8972, 2019 10 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-31314518
3.
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.
J Med Chem;
62(20): 8973-8995, 2019 10 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-31318208
4.
Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain.
Sci Transl Med;
11(502)2019 07 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-31341059
5.
Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).
J Med Chem;
62(7): 3228-3250, 2019 04 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30893553
6.
Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials.
J Med Chem;
62(5): 2265-2285, 2019 03 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30785748
7.
Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care.
PLoS One;
12(7): e0181782, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28742141
8.
Identification of potent tricyclic prodrug S1P1 receptor modulators.
Medchemcomm;
8(4): 725-729, 2017 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30108791
9.
Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator.
J Med Chem;
59(24): 11138-11147, 2016 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28002964
10.
Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers.
J Med Chem;
59(19): 9173-9200, 2016 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-27583770
11.
Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials.
ACS Med Chem Lett;
7(3): 283-8, 2016 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26985316
12.
Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity.
J Pharmacol Exp Ther;
354(2): 152-65, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26015463
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