Changes in colorectal cancer knowledge and screening intention among Ohio African American and Appalachian participants: The screen to save initiative.

African Americans and Appalachians experience greater incidence and mortality rates of colorectal cancer due to factors, such as reduced prevalence of screening. An educational session (the Screen to Save Initiative) was conducted to increase intent to screen for colorectal cancer among African Americans and Appalachians in Ohio. Using a community-based approach, from April to September 2017, 85 eligible participants were recruited in Franklin County and Appalachia Ohio. Participants completed a knowledge assessment on colorectal cancer before and after participating in either an educational PowerPoint session or a guided tour through an Inflatable Colon. Logistic regression models were used to determine what factors were associated with changes in colorectal cancer knowledge and intent to screen for colorectal cancer. The majority (71.79%) of participants gained knowledge about colorectal cancer after the intervention. Multivariate results showed that race (OR = 0.30; 95% CI: 0.11-0.80 for African Americans versus White participants) and intervention type (OR = 5.97; 95% CI: 1.94-18.43 for PowerPoint versus Inflatable Colon) were associated with a change in knowledge. The association between education and intent to screen was marginally statistically significant (OR = 0.42; 95% CI: 0.16-1.13 for college graduate versus not a college graduate). A change in colorectal cancer knowledge was not associated with intent to screen. Future educational interventions should be modified to increase intent to screen and screening for colorectal cancer. Further research with these modified interventions should aim to reduce disparities in CRC among underserved populations while listening to the voices of the communities.

The anticancer effect of chaetocin is enhanced by inhibition of autophagy.

Chaetocin is a fungal metabolite that possesses a potent antiproliferative activity in solid tumors by inducing cell death. Although recent studies have extended the role of chaetocin in tumors, the underlying molecular mechanisms such as the downstream cascade that induces cell death has not clearly been elucidated. In this study, we show that chaetocin is able to induce both apoptosis and autophagy in several hepatoma cell lines including HepG2, Hep3B and Huh7 cell lines. Moreover, we found that the inhibition of caspase-3/7 activity by z-VAD-fmk treatment was able to block chaetocin-mediated cell death, whereas blocking autophagy by Bafilomycin A1 or the knockdown of autophagy protein 5 enhanced cell death mediated by chaetocin. These findings suggest that chaetocin has a potent anticancer effect against hepatoma. Inhibition of autophagy may potentiate anticancer effects of chaetocin thus providing evidence that combined treatment with chaetocin and autophagy inhibitors will be an effective strategy for treating cancer.

End-of-Life care concepts in Journal of Neuroscience Nursing.

This descriptive study evaluated concepts relating to end-of-life care addressed in Journal of Neuroscience Nursing during a 10-year period. An analysis of 377 articles published from 1993 to 2002 found 40 articles addressing some area of end-of-life content. Of 2,558 pages reviewed, 201 pages (7.8%) contained end-of-life content. The primary areas of end-of-life care discussed in the articles were needs assessment for families, coping strategies and support systems, and recognition of family and caregiver needs. The most common diseases and disorders addressed were epilepsy, stroke, traumatic brain injury, multiple sclerosis, and Parkinson's disease. To increase overall content in the field of palliative and end-of-life care, authors can include end-of-life content in articles submitted for publication.

Nursing time and work in an acute rehabilitation setting.

Nursing staffing has long been recognized as a significant variable in a hospital budget even through the era of increased productivity and efficiency. In addition, patient acuity has been rising, and increasing demands on nursing personnel have been documented. These increased demands have affected nurse staffing, patient outcomes, and nurse retention, all of which have an impact on our healthcare system. Therefore, it is imperative that nursing time and work be examined in the acute rehabilitation setting--a setting in which research has been sparse. To estimate patient acuity, the activities of nursing personnel must be examined to establish timeframes for the care needed by patients. Previous studies have examined time and work according to pre-established patient acuity categories. California has passed legislation that requires mandatory nurse-staffing ratios in response to the concerns about the adequacy of patient care and safety. We did this study to assess the time and work related to patients with different diagnoses that are typically found in a rehabilitation unit. The data collected can be used to develop a patient acuity system. This study sought to identify how nurses spend their time so that hidden costs and important interventions can be addressed by an institution's administration.