[The experience in treatment of dengue fever using antiviral drug riamilovir in the Republic of Guinea (case report)].

Dengue fever is classified as one of the most common viral diseases with a transmission mechanism implemented through arthropod vectors. The expansion of of the Aedes aegypti mosquito is leading to a significant increase in the number of cases of dengue fever in more than 100 countries, highlighting the importance of developing and implementing specific prevention and treatment measures. Etiotropic drugs with proven efficacy against the pathogen are not registered, and the use of the vaccine is approved only among seropositive individuals. In this regard, pathogenetic treatment remains the main therapeutic strategy, however, work on the synthesis of antiviral drugs is being actively carried out. Due to the unique functions of non-structural proteins NS3 and NS5 in the viral replication cycle, they have become the main targets for studying the antiviral activity of a number of chemotherapy drugs. Of these proteins, due to the most conserved structure, the NS5 protein is a promising target for inhibition, however, success in obtaining a clinical effect using a number of available antiviral drugs has not been reached. This study describes the positive experience of using the nucleoside analogue riamilovir in the treatment of a patient with dengue fever in the Republic of Guinea.

[Features of lipid peroxidation and antioxidant defense of hens in ontogenesis and as a result of antioxidant action]. / Osobennosti protsessov peroksidnogo okisleniia lipidov i antioksidantnoi zashchity u kur v ontgogeneze i posle vozdeistviia antioksidantami.

The peculiarities of lipid peroxidation (LPO) and antioxidant defence of Leghorn hens in ontogenesis were studied. The action of stibyl biogeneous preparation in complex with dymethylsulfoxide and distinol synthetic preparation on hen organism antioxidant defence parameters were estimated. The results show that the antioxidant preparations don't render any effect on CAT and GPX activities, meanwhile SOD activity declines under antioxidant influence in the first period of feeding (7-35 days) but increases in the repeated administration admixtures (98-126 days) in comparison with the control group. Administration of antioxidants with fodder is accompanied by increasing the carotinoids, vitamins A and E content and mM levels decrease in hepatic tissue.