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Bioorg Med Chem Lett
; 15(5): 1501-4, 2005 Mar 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15713416
RESUMEN
The synthesis, SAR and biological evaluation of a series of ureas that activate glucokinase, a target for diabetes therapy as a result of its critical role in the regulation of whole-body glucose homeostasis, are described. Some of the urea-containing glucokinase activators lowered blood glucose levels in vivo following oral dosing to C57BL/6J mice.