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1.
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate-conditioned Fanconi anemia mice.
Blood;
143(21): 2201-2216, 2024 May 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38447038
2.
Fertility-preserving myeloablative conditioning using single-dose CD117 antibody-drug conjugate in a rhesus gene therapy model.
Nat Commun;
14(1): 6291, 2023 10 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37828021
3.
A CD45-targeted antibody-drug conjugate successfully conditions for allogeneic hematopoietic stem cell transplantation in mice.
Blood;
139(11): 1743-1759, 2022 03 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34986233
4.
Antibody Co-Administration Can Improve Systemic and Local Distribution of Antibody-Drug Conjugates to Increase In Vivo Efficacy.
Mol Cancer Ther;
20(1): 203-212, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33177153
5.
Peptide-Cleavable Self-immolative Maytansinoid Antibody-Drug Conjugates Designed To Provide Improved Bystander Killing.
ACS Med Chem Lett;
10(10): 1393-1399, 2019 Oct 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31620224
6.
Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs).
Bioorg Med Chem Lett;
29(17): 2455-2458, 2019 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31350125
7.
A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs).
Mol Cancer Ther;
17(3): 650-660, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29440292
8.
The Antitumor Activity of IMGN529, a CD37-Targeting Antibody-Drug Conjugate, Is Potentiated by Rituximab in Non-Hodgkin Lymphoma Models.
Neoplasia;
19(9): 661-671, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28753442
9.
Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC.
J Med Chem;
60(12): 5002-5014, 2017 06 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28549219
10.
Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates.
Bioconjug Chem;
28(5): 1371-1381, 2017 05 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-28388844
11.
Mirvetuximab Soravtansine (IMGN853), a Folate Receptor Alpha-Targeting Antibody-Drug Conjugate, Potentiates the Activity of Standard of Care Therapeutics in Ovarian Cancer Models.
Neoplasia;
18(12): 775-784, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27889646
12.
Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates.
Bioconjug Chem;
27(7): 1588-98, 2016 07 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-27174129
13.
A New Triglycyl Peptide Linker for Antibody-Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells.
Mol Cancer Ther;
15(6): 1311-20, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27197308
14.
Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing.
Bioconjug Chem;
26(11): 2261-78, 2015 Nov 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-26355774
15.
Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV).
Proc Natl Acad Sci U S A;
108(17): 6739-44, 2011 Apr 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-21502533
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