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BACKGROUND: Talent transfer (TT) program is an appropriate approach to address the talent gap evident in specific sports activities, while little is known about the injury characteristics of snowboarding athletes involved in the TT program. OBJECTIVE: To determine the epidemiology of injuries among snowboarders involved in the TT program. METHODS: A total of 244 athletes who were not previously engaged in winter sports were selected for training in snowboarding that lasted for 109 days. The injuries and at-risk exposures (A-Es) data were recorded by physicians. Injury rates (IRs), incidence rate ratios (IRRs), and injury proportion ratios (IPRs) were calculated and compared by sex and age groups. RESULTS: The overall and time loss (TL) IR were 32.4/1000 A-Es and 12.2/1000 A-Es respectively. The overall and non-time loss (NTL) IRR were higher for female athletes than for male athletes. Additionally, the overall IRR and TL-IRR for female athletes were higher in those athletes who aged ≤15 years old. Over 93% of TL injuries resulted in participation restriction time of ≤7 days (male athletes, 93.94%; female athletes, 94.10%). Trunk (28.43%), knee joints (21.33%), and hand/wrist (16.53%) were found as the common sites of injury in both female and male athletes. The most frequent type of injury was contusion (male athletes: 53.00%, female athletes: 59.10%) resulted from ground/apparatus contact (male athletes: 75.10%, female athletes: 75.20%). CONCLUSION: The risk injury among snowboarding athletes involved in the TT program during the first snow season training was found noticeable, especially for younger female athletes. The high incidence of ground/apparatus contact-related injuries suggested the necessity of specifically designed training programs and braces for snowboarding athletes involved in the TT program.
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Atletas , Traumatismos en Atletas , Esquí , Humanos , Femenino , Masculino , Estudios Prospectivos , Traumatismos en Atletas/epidemiología , Adolescente , Adulto , Esquí/lesiones , Adulto Joven , Incidencia , Factores de RiesgoRESUMEN
Teratoma, due to its remarkable ability to differentiate into multiple cell lineages, is a valuable model for studying human embryonic development. The similarity of the gene expression and chromatin accessibility patterns in these cells to those observed in vivo further underscores its potential as a research tool. Notably, teratomas derived from human naïve (pre-implantation epiblast-like) pluripotent stem cells (PSCs) have larger embryonic cell diversity and contain extraembryonic lineages, making them more suitable to study developmental processes. However, the cell type-specific epigenetic profiles of naïve PSC teratomas have not been yet characterized. Using single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq), we analyzed 66,384 cell profiles from five teratomas derived from human naïve PSCs and their post-implantation epiblast-like (primed) counterparts. We observed 17 distinct cell types from both embryonic and extraembryonic lineages, resembling the corresponding cell types in human fetal tissues. Additionally, we identified key transcription factors specific to different cell types. Our dataset provides a resource for investigating gene regulatory programs in a relevant model of human embryonic development.
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Cromatina , Células Madre Pluripotentes , Análisis de la Célula Individual , Teratoma , Humanos , Teratoma/genética , Teratoma/patología , Células Madre Pluripotentes/metabolismo , Linaje de la Célula , Factores de Transcripción/genéticaRESUMEN
Background: Atrial fibrillation (AF), which occurs four to six times more frequently in hypertrophic cardiomyopathy (HCM) patients than in the general population, is the most common persistent arrhythmia and has a substantial therapeutic consequence. In HCM patients, there are currently no discovered signs that could be utilized to identify AF. Methods: From 2018 to 2022, 493 individuals with a continuous diagnosis of HCM were examined at Beijing Anzhen Hospital. AF was proven using routine electrocardiography (ECG), 24-hour Holter ECGs, or bedside ECGs. Echocardiography and blood tests were performed for all patients. Analysis and comparison of the traits were performed in HCM patients with AF (n = 77) and without AF (n = 416). Results: Age (p < 0.001), prevalence of ventricular tachycardia (VT, p < 0.001), prevalence of pulmonary artery hypertension (p = 0.027), and albumin-to-globulin ratio (AGR, p = 0.046) were all significantly higher in patients with AF, compared to patients without AF. In multivariate logistic analysis, age (odds ratio [OR], 1.063; 95% confidence interval [CI], 1.032-1.095; p < 0.001), history of VT (OR, 2.702; 95% CI, 1.007-7.255; p = 0.048), AGR (OR, 3.477; 95% CI, 1.417-8.536; p = 0.007), left atrial diameter (OR, 1.132; 95% CI, 1.073-1.194; p < 0.001), left ventricular end-diastolic diameter (OR, 0.861; 95% CI, 0.762-0.974; p = 0.017), left ventricular end-systolic diameter (OR, 1.239; 95% CI, 1.083-1.417; p = 0.002), and peak A wave velocity (OR, 0.983; 95% CI, 0.972-0.994; p = 0.002) were independently associated with AF in HCM patients. In the receiver operating characteristic curve analysis, the area under the curve for the established model was 0.819 (95% CI, 0.755-0.883, p = 0.033), with a sensitivity and specificity of 0.763 and 0.816, respectively, for AF occurrence in HCM patients. Conclusions: In individuals with HCM, a history of VT and a higher AGR are independently linked to AF. Further investigation is necessary to determine whether increased AGR represents a risk factor for embolic stroke or cardiovascular death.
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Radiation-induced heart disease (RIHD), characterized by severe oxidative stress and immune dysregulation, is a serious condition affecting cancer patients undergoing thoracic radiation. Unfortunately, clinical interventions for RIHD are lacking. Selenium (Se) is a trace element with excellent antioxidant and immune-modulatory properties. However, its application in heart radioprotection remains challenging. Herein, we developed a novel bioactive Cordyceps militaris-based Se oral delivery system (Se@CM), which demonstrated superior radioprotection effects in vitro against X-ray-induced damage in H9C2 cells through suppressing excessive ROS generation, compared to the radioprotectant Amifostine. Moreover, Se@CM exhibited exceptional cardioprotective effects in vivo against X-ray irradiation, reducing cardiac dysfunction and myocardial fibrosis by balancing the redox equilibrium and modulating the expression of Mn-SOD and MDA. Additionally, Se@CM maintained immuno-homeostasis, as evidenced by the upregulated population of T cells and M2 macrophages through modulation of selenoprotein expression after irradiation. Together, these results highlight the remarkable antioxidant and immunity modulation properties of Se@CM and shed light on its promising application for cardiac protection against IR-induced disease. This research provides valuable insights into developing effective strategies for preventing and managing RIHD.
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We report three patients with screw-in lead perforation in the right atrial free wall not long after device implantation. All the patients complained of intermittent stabbing chest pain associated with deep breathing during the implantation. The "dry" epicardial puncture was utilized to avoid hemopericardium during lead extraction in the first case. The atrial electrode was repositioned in all cases and replaced by a new passive fixation lead in two patients with resolution of the pneumothorax or pericardial effusion. A literature review of 50 reported cases of atrial lead perforation was added to the findings in our case report.
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In contrast to rodents, the mechanisms underlying human trophectoderm and early placenta specification are understudied due to ethical barriers and the scarcity of embryos. Recent reports have shown that human pluripotent stem cells (PSCs) can differentiate into trophectoderm (TE)-like cells (TELCs) and trophoblast stem cells (TSCs), offering a valuable in vitro model to study early placenta specification. Here, we demonstrate that the VGLL1 (vestigial-like family member 1), which is highly expressed during human and non-human primate TE specification in vivo but is negligibly expressed in mouse, is a critical regulator of cell fate determination and self-renewal in human TELCs and TSCs derived from naïve PSCs. Mechanistically, VGLL1 partners with the transcription factor TEAD4 (TEA domain transcription factor 4) to regulate chromatin accessibility at target gene loci through histone acetylation and acts in cooperation with GATA3 and TFAP2C. Our work is relevant to understand primate early embryogenesis and how it differs from other mammalian species.
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Células Madre Pluripotentes , Factores de Transcripción , Embarazo , Femenino , Humanos , Ratones , Animales , Linaje de la Célula/genética , Factores de Transcripción/genética , Trofoblastos/fisiología , Diferenciación Celular/genética , Mamíferos , Primates , Proteínas de Unión al ADN/genética , Factores de Transcripción de Dominio TEARESUMEN
The chemical complexity and toxicity of volatile organic compounds (VOCs) are primarily encountered through intensive anthropogenic emissions in suburban areas. Here, pollution characteristics, impacts on secondary pollution formation, and health risks were investigated through continuous in-field measurements from 1-30 June 2020 in suburban Nanjing, adjacent to national petrochemical industrial parks in China. On average, the total VOCs concentration was 34.47 ± 16.08 ppb, which was comprised mostly by alkanes (41.8%) and halogenated hydrocarbons (29.4%). In contrast, aromatics (17.4%) dominated the ozone formation potential (OFP) and secondary organic aerosol formation potential (SOAFP) with 59.6% and 58.3%, respectively. Approximately 63.5% of VOCs were emitted from the petrochemical industry and from solvent usage based on source apportionment results, followed by biogenic emissions of 22.3% and vehicle emissions of 14.2%. Of the observed 46 VOC species, hexachlorobutadiene, dibromoethane, butadiene, tetrachloroethane, and vinyl chloride contributed as high as 98.8% of total carcinogenic risk, a large fraction of which was ascribed to the high-level emissions during ozone pollution episodes and nighttime. Therefore, the mitigation of VOC emissions from petrochemical industries would be an effective way to reduce secondary pollution and potential health risks in conurbation areas.
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Large-scale public health emergencies may exert significant adverse effects on market sentiment. This study utilizes interrupted time series analysis (ITSA) to explore the shift in Chinese investors' sentiment in response to the uncertainties due to the outbreak of the COVID-19 pandemic. The empirical findings demonstrate that COVID-19 had a notable impact on investor sentiment within China's stock markets. Before the outbreak of COVID-19, investor sentiment had been on an upward trend. However, since the onset of the pandemic, there has been a sustained decline in investor sentiment, aligning with the downward trend observed in China's stock markets. Interestingly, the immediate effect of the COVID-19 intervention was positive, briefly boosting investor sentiment. As of 2023, with the conclusion of the pandemic and the Chinese government's decision to end the zero COVID-19 policy, we anticipate resurgence in investor sentiment within China's stock markets.
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Atomic-level structure engineering has proven indispensable for fast ion transport kinetics. Herein, a unique framework of NiSe/Ni heterostructure with abundant heterointerface encapsulated hollow carbon spheres, namely NiSe/Ni@C, is synthesized as an anode for SIBs. The NiSe/Ni@C electrode delivers enhanced Na+ storage performance in terms of high specific capacity (490 mA h g-1) and excellent rate capability (546 mA h g-1) at a current of 5.0 A g-1 over 2000 cycles. This study can provide in-depth insights into the interface effect in hybrid structures and shed light on designing energy storage materials.
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Heavy metals are harmful environmental pollutants that have attracted widespread attention, attributed to their health hazards to humans and animals. Due to the non-degradable property of heavy metals, organisms are inevitably exposed to heavy metals such as arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg). Several studies revealed that heavy metals can cause reproductive damage by the excessive production of reactive oxygen species (ROS), which exacerbates oxidative stress, inflammation, and endocrine disruption. Natural antioxidants, mainly polyphenols, carotenoids, and vitamins, have been shown to mitigate heavy metal-induced reproductive toxicity potentially. In this review, accumulated evidences on the influences of four non-essential heavy metals As, Cd, Pb, and Hg on both males and females reproductive system were established. The purpose of this review is to explore the potential mechanisms of the effects of heavy metals on reproductive function and point out the potential biomarkers of natural antioxidants interventions toward heavy metal-induced reproductive toxicity. Notably, increasing evidence proven that the regulations of hypothalamic-pituitary-gonadal axis, Nrf2, MAPK, or NF-κB pathways are the important mechanisms for the amelioration of heavy metal induced reproductive toxicity by natural antioxidants. It also provided a promising guidance for prevention and management of heavy metal-induced reproductive toxicity.
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Phenolic acids (PAs) secreted by donor plants suppress the growth of their susceptible plant neighbours. However, how structurally diverse ensembles of PAs are perceived by plants to mediate interspecific competition remains a mystery. Here we show that a plant stress granule (SG) marker, RNA-BINDING PROTEIN 47B (RBP47B), is a sensor of PAs in Arabidopsis. PAs, including salicylic acid, 4-hydroxybenzoic acid, protocatechuic acid and so on, directly bind RBP47B, promote its phase separation and trigger SG formation accompanied by global translation inhibition. Salicylic acid-induced global translation inhibition depends on RBP47 family members. RBP47s regulate the proteome rather than the absolute quantity of SG. The rbp47 quadruple mutant shows a reduced sensitivity to the inhibitory effect of the PA mixture as well as to that of PA-rich rice when tested in a co-culturing ecosystem. In this Article, we identified the long sought-after PA sensor as RBP47B and illustrated that PA-induced SG-mediated translational inhibition was one of the PA perception mechanisms.
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Arabidopsis , Ecosistema , Arabidopsis/genética , Ecología , SalicilatosRESUMEN
The relationship framework between electroencephalogram (EEG) signals and subjective perception during pilots' missions was established to improve pilots' training efficiency and flight safety. Primarily, this study constructs a real flight scene through virtual reality (VR) and then obtains EEG data in simulated scenes. Researchers use VR technology to build a mission simulation room and then acquire EEG data from participants wearing EEG acquisition devices in the simulated room. The experimental process is divided into flight simulation and a questionnaire survey. Based on the participants' EEG analysis, the researchers verified the changes of ß rhythm under a high-difficulty operation mission. In addition, this study infers the mechanism of affecting pilots' mental workload under high-difficulty operation by analyzing the correlation between subjective questionnaire results and ß rhythms. The results showed that in the context of pilots performing flight missions in the aircraft space environment, the pilots' mental load had the most excellent rhythmic relationship with the regions representing ß rhythm. Therefore, a comprehensive experimental framework constructed in this study based on virtual simulation space to analyze the relationship between EEG and NASA-TLX subjective questionnaire provides a set of more accurate reference information for the design of a pilot training system based on pilot training efficiency and flight safety.
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United States National Aeronautics and Space Administration , Realidad Virtual , Estados Unidos , Humanos , Aeronaves , Carga de Trabajo , ElectroencefalografíaRESUMEN
Feature extraction is a key step in hyperspectral image change detection. However, many targets with great various sizes, such as narrow paths, wide rivers, and large tracts of cultivated land, can appear in a satellite remote sensing image at the same time, which will increase the difficulty of feature extraction. In addition, the phenomenon that the number of changed pixels is much less than unchanged pixels will lead to class imbalance and affect the accuracy of change detection. To address the above issues, based on the U-Net model, we propose an adaptive convolution kernel structure to replace the original convolution operations and design a weight loss function in the training stage. The adaptive convolution kernel contains two various kernel sizes and can automatically generate their corresponding weight feature map during training. Each output pixel obtains the corresponding convolution kernel combination according to the weight. This structure of automatically selecting the size of the convolution kernel can effectively adapt to different sizes of targets and extract multi-scale spatial features. The modified cross-entropy loss function solves the problem of class imbalance by increasing the weight of changed pixels. Study results on four datasets indicate that the proposed method performs better than most existing methods.
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Due to optical noise, electrical noise, and compression error, data hyperspectral remote sensing equipment is inevitably contaminated by various noises, which seriously affect the applications of hyperspectral data. Therefore, it is of great significance to enhance hyperspectral imaging data quality. To guarantee the spectral accuracy during data processing, band-wise algorithms are not suitable for hyperspectral data. This paper proposes a quality enhancement algorithm based on texture search and histogram redistribution combined with denoising and contrast enhancement. Firstly, a texture-based search algorithm is proposed to improve the accuracy of denoising by improving the sparsity of 4D block matching clustering. Then, histogram redistribution and Poisson fusion are used to enhance spatial contrast while preserving spectral information. Synthesized noising data from public hyperspectral datasets are used to quantitatively evaluate the proposed algorithm, and multiple criteria are used to analyze the experimental results. At the same time, classification tasks were used to verify the quality of the enhanced data. The results show that the proposed algorithm is satisfactory for hyperspectral data quality improvement.
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Testicular hyperthermia induced by unhealthy living habits and pathological or occupational factors can cause spermatogenic dysfunction with an outcome of sub-fertility or even infertility. Cyanidin-3-O-glucoside (C3G) is the most typical anthocyanin in foods that has been recognized as an antioxidant with promising protection for male reproduction. However, its specific effect against testicular hyperthermia and the mechanisms involving its primary gastrointestinal metabolite protocatechuic acid (PCA) are still unexplored. In the present study, testicular hyperthermia in mice was established by employing a single hot water bath at 43 °C for 30 min. C3G and PCA were intragastrically given to investigate their prevention ability against heat stress-induced testicular damage. It was found that C3G and PCA restored the external diameter and thickness, and alleviated atrophy and vacuolation of seminiferous tubules. Simultaneously, C3G and PCA enhanced testicular heat stress tolerance through reducing superfluous eIF2α phosphorylation and stress granule formation. C3G and PCA effectively improved the testicular antioxidant system and regulated the IRE1α-XBP1 pathway, contributing to mitigatory spermatogenesis dysfunction and testicular damage. This finding revealed that anthocyanins were the novel compounds for alleviating testicular damage, and provided a reliable theoretical basis for improving male fertility disturbed by heat stress.
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Antocianinas , Antioxidantes , Ratones , Masculino , Animales , Antocianinas/farmacología , Antocianinas/metabolismo , Antioxidantes/farmacología , Endorribonucleasas , Glucósidos/farmacología , Glucósidos/metabolismo , Proteínas Serina-Treonina Quinasas , Respuesta al Choque TérmicoRESUMEN
Determination of dominant chemical pathways toward the formation of nocturnal secondary organic aerosols (SOA) remains ambiguous by which nitrogen oxides (NOx) always affect oxidation of volatile alkenes. Here, comprehensive chamber simulations on dark isoprene ozonolysis were conducted under different nitrogen dioxides (NO2) mixing ratios to exam multiple functionalized isoprene oxidation products. Aside from that the oxidation processes were concurrently driven by nitrogen radical (NO3) and small hydroxyl radicals (OH), ozone (O3) cycloaddition at isoprene was launched initially regardless of NO2 to rapidly form first-generation oxidation products, i.e., carbonyls and Criegee intermediates (CI) referred to carbonyl oxides. They could further undergo complicated self- and cross-reactions to produce alkylperoxy radicals (RO2). Corresponding to yields of the C5H10O3 tracer, weak OH pathway at night was credited to ozonolysis of isoprene but suppressed by unique NO3 chemistry. Following the ozonolysis of isoprene, NO3 played a crucial supplementary role in nighttime SOA formation. The ensuing production of gas-phase nitrooxy carbonyls (the first-generation nitrates) became dominant in the production of a sizeable pool of organic nitrates (RO2NO2). By contrast, isoprene dihydroxy dinitrates (C5H10N2O8) were outstanding with the elevated NO2, related to typical second-generation nitrates. As such, the yielding number concentrations of dark SOA were promoted to approximately 1.8 × 104 cm-3 but presented a nonlinear relation with excess high-NO2 condition. This study provides valuable insights into importance of multifunctional organic compounds from alkene oxidation to constitute nighttime SOA.
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Contaminantes Atmosféricos , Ozono , Nitratos/química , Contaminantes Atmosféricos/análisis , Dióxido de Nitrógeno , Ozono/química , Aerosoles/químicaRESUMEN
Atrial flutter (AFL) is the second most common atrial tachyarrhythmia after atrial fibrillation. Catheter ablation (CA) for typical AFL is well-established and has a high success rate and adequate safety. However, sick sinus syndrome (SSS) occasionally occurs when long-term, persistent AFL is terminated by ablation. Sinus node function cannot be assessed during AFL, and the preoperative prediction of underlying SSS has not yet been investigated. When this situation occurs, pacemaker implantation is often necessary. Here, we report a case of SSS after persistent AFL CA.
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Fibrilación Atrial , Aleteo Atrial , Ablación por Catéter , Humanos , Aleteo Atrial/etiología , Aleteo Atrial/cirugía , Síndrome del Seno Enfermo/cirugía , Electrocardiografía , Fibrilación Atrial/cirugía , Ablación por Catéter/efectos adversos , Resultado del TratamientoRESUMEN
BACKGROUND: In recent years, the difference in outcomes of radiofrequency catheter ablation (RFCA) in persistent atrial fibrillation patients has risen. In particular, biological sex seems involved in a different response to the AF ablation procedure. In our study, we analyzed the AF recurrences after RFCA assessing the other association between male/female patients with the outcomes. METHODS: We enrolled 106 patients (74.5% men) with persistent atrial fibrillation with scheduled follow-up. The baseline clinical characteristics and AF recurrence after RFCA were compared between men and women. Cox regression analyses were performed to determine the risk predictors of AF recurrence. RESULTS: The proportion of RFCA in women was lower than that in men. Men with persistent AF were younger than women (58.6 ± 10.4 years vs. 65.1 ± 8.7 years, respectively; p = 0.003). The left atrium (LA) diameter was higher in males (43.7 ± 4.6 mm vs. 41.3 ± 5.5 mm; p = 0.028), and the level of left heart ejection fraction (LVEF) was higher in females (59.4 ± 6.9% vs. 64.1 ± 5.5%; p = 0.001). Sex differences in AF recurrence after RFCA were significant during the median 24.4-month (interquartile range: 15.2-30.6 months) follow-up period, and the recurrence rate of AF in women was significantly higher than that in men (p = 0.005). Univariable Cox regression analysis showed that female sex was a risk factor for persistent AF recurrence after RFCA [HR: 2.099 (1.087-4.053)]. Univariate Cox regression analysis revealed that non-PV ablation not associated with AF recurrence [HR: 1.003 (0.516-1.947)]. CONCLUSION: In a monocentric cohort of persistent AF patients, the female biological sex was associated with a higher risk of AF recurrence after RFCA.
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Fibrilación Atrial , Ablación por Catéter , Femenino , Humanos , Masculino , Fibrilación Atrial/diagnóstico , Fibrilación Atrial/cirugía , Caracteres Sexuales , Recurrencia , Resultado del Tratamiento , Ablación por Catéter/efectos adversos , Ablación por Catéter/métodosRESUMEN
This work comprehensively investigated the constituents, sources, and associated health risks of ambient volatile organic compounds (VOCs) sampled during the autumn of 2020 in urban Nanjing, a megacity in the densely populated Yangtze River Delta region in China. The total VOC (TVOC, sum of 108 species) concentration was determined to be 29.04 ± 14.89 ppb, and it was consisted of alkanes (36.9%), oxygenated VOCs (19.9%), halogens (19.1%), aromatics (9.9%), alkenes (8.9%), alkynes (4.9%), and others (0.4%). The mean TVOC/NOx (ppbC/ppbv) ratio was only 3.32, indicating the ozone control is overall VOC-limited. In terms of the ozone formation potential (OFP), however, the largest contributor became aromatics (41.9%), followed by alkenes (27.6%), and alkanes (16.9%); aromatics were also the dominant species in secondary organic aerosol (SOA) formation, indicative of the critical importance of aromatics reduction to the coordinated control of ozone and fine particulate matter (PM2.5). Mass ratios of ethylbenzene/xylene (E/X), isopentane/n--pentane (I/N), and toluene/benzene (T/B) ratios all pointed to the significant influence of traffic on VOCs. Positive matrix factorization (PMF) revealed five sources showing that traffic was the largest contributor (29.2%), particularly in the morning. A biogenic source, however, became the most important source in the afternoon (31.3%). The calculated noncarcinogenic risk (NCR) and lifetime carcinogenic risk (LCR) of the VOCs were low, but four species, acrolein, benzene, 1,2-dichloroethane, and 1,2-dibromoethane, were found to possess risks exceeding the thresholds. Furthermore, we conducted a multilinear regression to apportion the health risks to the PMF-resolved sources. Results show that the biogenic source instead of traffic became the most prominent contributor to the TVOC NCR and its contribution in the afternoon even outpaced the sum of all other sources. In summary, our analysis reveals the priority of controls of aromatics and traffic/industrial emissions to the efficient coreduction of O3 and PM2.5; our analysis also underscores that biogenic emissions should be paid special attention if considering the direct health risks of VOCs.
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This study aimed to establish a model that predicts atrial fibrillation (AF) recurrence after catheter ablation using clinical risk factors and biomarkers. We used a prospective cohort study, including 230 consecutive persistent AF patients successfully treated with catheter ablation from January 2019 to December 2020 in our hospital. AF recurrence was followed-up after catheter ablation, and clinical risk factors and biomarkers for AF recurrence were analyzed. AF recurred after radiofrequency ablation in 72 (31%) patients. Multiple multivariate logistic regression analysis demonstrated that tissue inhibitor of metalloproteinase-1 (TIMP-1) and left atrium diameter (LAd) were closely associated with AF recurrence. The prediction model constructed by combining TIMP-1 and LAd effectively predicted AF recurrence. Additionally, the model's performance discrimination, accuracy, and calibration were confirmed through internal validation using bootstrap resampling (1,000 times). The model showed good fitting (Hosmer-Lemeshow goodness chi-square 3.76138, p = 0.926) and had a superior discrimination ability (the area under the receiver operation characteristic curve0.917; 95% CI 0.882-0.952). The calibration curve showed good agreement between the predicted probability and the actual probability. Moreover, the decision curve analysis (DCA) showed the clinical useful of the nomogram. In conclusion, our predictive model based on serum TIMP-1 and LAd levels could predict AF recurrence after catheter ablation.