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1.
Int J Biol Macromol ; 277(Pt 4): 134337, 2024 Aug 05.
Artículo en Inglés | MEDLINE | ID: mdl-39111482

RESUMEN

Hydrogels as skin wound dressings have been extensively studied owing to their good flexibility and biocompatibility. Nevertheless, the mechanical performance, adhesive capability, antifouling and antibacterial properties of conventional hydrogels are still unsatisfactory, which hinder the application of hydrogel for cutaneous healing. Here, we developed a novel biocompatible multifunctional hydrogel with super flexible, fatigue resistant, antifouling and self-adhesive capability for effective wound healing, where naturally rigid polymers including quaternized chitosan (QCS) and Tunicate cellulose nanocrystals (TCNCs) are used as bioactive cross-linkers and reinforcers to endow the hydrogel with excellent mechanical and antibacterial property, and the synergistic contributions from the poly(acrylic acid/methacrylate anhydride dopamine/sulfobetaine methacrylate) (poly(AA/DMA/SBMA)) chains and QCS endow the hydrogel with excellent adhesive property, antioxidant, antifouling and pH-responsive sustained drug release capabilities. The optimized hydrogel exhibited high tensile strength (77.69 KPa), large tensile strain (889.9 %), large toughness (307.51KJ.m-3), high adhesive strength (35.57 KPa) and ideal compressive property. The in vivo infected full-thickness skin model demonstrated that the hydrogel with vanvomycin sustained release ability efficiently improved the granulation tissue formation, facilitating collagen deposition and reducing inflammatory expression, thus effectively accelerating wound healing. This superiorly skin-adhesive antibacterial biocompatible hydrogel appears to be a promising candidate for wound therapy.

2.
ACS Nano ; 2024 Aug 23.
Artículo en Inglés | MEDLINE | ID: mdl-39178055

RESUMEN

Flexible ferroelectric materials are in high demand in emerging energy harvesting and self-powered sensing electronics. However, current flexible ferroelectric polymers, such as poly(vinylidene fluoride) (PVDF) and P(VDF-co-trifluoroethylene) [P(VDF-TrFE)], cannot fulfill the requirement of emerging applications because of their low piezoelectric/pyroelectric performance. In this work, using organic-inorganic hybrid perovskite [(4-aminotetrahydropyran)2PbBr2Cl2] ferroelectric nanorods as reinforcement and P(VDF-TrFE) as the matrix, we prepared flexible core-sheath piezoelectric nanofibers and pyroelectric nanocomposite films. The core-sheath nanofibers possess a record-high piezoelectric coefficient of 78.1 pC·N-1, and the output voltage reaches to 192 V, with the maximum power density of 1.04 W·m-2. On the other hand, the nanocomposite film exhibits a high pyroelectric coefficient of 58.2 µC·m-2·K-1 at 333 K, which yields a voltage of 6.1 V under 6.6 K temperature fluctuation. An integrated flexible sensing device was prepared by combining piezoelectric nanofibers and pyroelectric films, which can wirelessly detect vibration and temperature fluctuation simultaneously. The integrated device is suitable for pipelines, power equipment, and other scenarios, where vibration and temperature need to be monitored at the same time.

3.
Heliyon ; 10(15): e35750, 2024 Aug 15.
Artículo en Inglés | MEDLINE | ID: mdl-39170407

RESUMEN

Objective: To investigate the effect of electroacupuncture (EA) on retinal function in guinea pigs with negative lens-induced myopia (LIM) by inhibiting the RhoA/ROCK2 signaling pathway. Methods: Guinea pigs were randomly divided into normal control (NC) group, LIM group, EA group, SHAM acupoint (SHAM) group, and electro-acupuncture + ROCK pathway inhibitor Y27632 (EA + Y27632) group. The refraction, axial length, retinal blood flow density, choroidal vascular index, retinal physiological function, the contents of total antioxidant capacity (T-AOC), catalase (CAT), glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA) of each group were determined. The changes in retinal tissue structure were observed by hematoxylin and eosin (H&E) staining, and the expression of the RhoA/ROCK2 signaling pathway-related molecules in the retina was measured by real-time quantitative polymerase chain reaction (qPCR) and Western blot. Results: Myopic refraction, AL, and MDA content in the LIM and SHAM groups were significantly increased, retinal blood flow density and CVI, SOD, GSH, CAT, T-AOC content were decreased. After EA intervention, myopic refraction, AL, and MDA content decreased, retinal blood flow density and CVI, SOD, GSH, CAT, T-AOC content were increased. H&E staining showed that the thickness of the guinea pig retina, the thickness of the inner and outer layers of the nucleus, and the number of cells were significantly increased after EA intervention. qPCR and western blot analyses showed that the expression of RhoA、ROCK2、MLC、CollagenⅠ、MMP-2、TIMP-2 and α-SMA were elevated in the LIM and SHAM group than those in the NC group. Compared with the LIM group, the expression of EA group was significantly decreased. Conclusions: Electroacupuncture can improve retinal function by improving retinal blood flow, reducing retinal oxidative damage, inhibiting RhoA/ROCK2 signaling pathway and controlling extracellular matrix remodeling, thus delaying the occurrence and development of myopia.

4.
ACS Appl Mater Interfaces ; 16(28): 36620-36627, 2024 Jul 17.
Artículo en Inglés | MEDLINE | ID: mdl-38954756

RESUMEN

Flexible thermoelectric generators can directly convert thermal energy harvested from the human body into electricity. The Ag2Se flexible film, a promising material for wearable thermoelectric generators, normally demonstrates an inferior electrical transport property due to its weakened in-plane mobility. In this study, the in-plane electrical transport properties of flexible Ag2Se films were optimized by alloying with additional sulfur. This optimization is achieved by leveraging the differences in elemental electronegativity and the preferred orientation of the Ag2Se films. The sulfur-alloyed Ag2Se thin film, with a nominal ratio of 3 atom %, can reach a maximum mobility of 1150 cm-2 V-1 s-1 at 300 K. So, the optimized room-temperature power factor increases to 1935 µW m-1 K-2. Furthermore, the Ag2Se film alloyed with 3 atom % sulfur exhibits excellent flexibility even after 1000 bending cycles with a radius of 5 mm, characterized by a relative resistance increment of less than 3%. In addition, the corresponding π-type flexible thermoelectric generator possesses a maximum power density of 51 W m-2 at a temperature difference of 50 K.

5.
Chest ; 2024 Jul 25.
Artículo en Inglés | MEDLINE | ID: mdl-39067508

RESUMEN

BACKGROUND: Metagenomic next-generation sequencing (mNGS) was previously established as a method that can increase the pathogen identification rate in patients with severe community-acquired pneumonia (SCAP). RESEARCH QUESTION: What is the impact on clinical outcomes of mNGS of BALF in ICU patients with SCAP? STUDY DESIGN AND METHODS: A multicenter, randomized, open-label clinical trial was conducted in 10 ICUs. Patients were randomized in a 1:1 ratio to undergo BALF with the conventional microbiological tests (CMTs) only (CMT group) or both BALF with mNGS and CMTs (mNGS group). The primary outcome was the time to clinical improvement, defined as the time from randomization to either an improvement of two points on a six-category ordinal scale or discharge from the ICU, whichever occurred first. RESULTS: A total of 349 patients were randomized between January 1, 2021, to November 18, 2022, of whom 170 were assigned to the CMT group and 179 to the mNGS group. In the intention-to-treat analysis, the time to clinical improvement was better in the mNGS group than that in the CMT group (10 d vs. 13 d, difference: -2.0 [95% CI = -3.0 to 0.0]). Similar results were obtained in the per-protocol analysis. The proportion of patients with clinical improvement within 14 d was significantly higher in the mNGS group (62.0%) than that in the CMT group (46.5%). There was no significant difference in other secondary outcomes. CONCLUSION: MNGS combined with CMTs reduced the time to clinical improvement for patients with SCAP, compared to the use of CMTs alone.

6.
Micromachines (Basel) ; 15(6)2024 May 23.
Artículo en Inglés | MEDLINE | ID: mdl-38930655

RESUMEN

Conventional microfluidic systems that rely on capillary force have a fixed structure and limited sensitivity, which cannot meet the demands of clinical applications. Herein, we propose a dual-drive microfluidic device for sensitive and flexible detection of multiple pathogenic microorganisms antigens/antibodies. The device comprises a portable microfluidic analyzer and a dual-drive microfluidic chip. Along with capillary force, a second active driving force is provided by a removable self-driving valve in the waste chamber. The interval between these two driving forces can be adjusted to control the reaction time in the microchannel, optimizing the formation of antigen-antibody complexes and enhancing sensitivity. Moreover, the material used in the self-driving valve can be changed to adjust the active force strength needed for different tests. The device offers quantitative analysis for respiratory syncytial virus antigen and SARS-CoV-2 antigen using a 35 µL sample, delivering results within 5 min. The detection limits of the system were 1.121 ng/mL and 0.447 ng/mL for respiratory syncytial virus recombinant fusion protein and SARS-CoV-2 recombinant nucleoprotein, respectively. Although the dual-drive microfluidic device has been used for immunoassay for respiratory syncytial virus and SARS-CoV-2 in this study, it can be easily adapted to other immunoassay applications by changing the critical reagents.

7.
ACS Appl Mater Interfaces ; 16(25): 32773-32783, 2024 Jun 26.
Artículo en Inglés | MEDLINE | ID: mdl-38865582

RESUMEN

The development of new electromagnetic absorbing materials is the main strategy to address electromagnetic radiation. Once traditional electromagnetic wave-absorbing materials are prepared, it is difficult to dynamically change their electromagnetic wave-absorbing performance. Facing the complexity of the information age and the rapid development of modern radar, it is significant to develop intelligent modulation of electromagnetic wave-absorbing materials. Here, CNTs/VO2/ANF composite aerogels with dynamic frequency tunability and switchable absorption on/off were synthesized. Based on the phase change behavior of VO2, the degree of polarization and interfacial effects of multiple heterogeneous interfaces between VO2 and CNTs and aramid nanofibers (ANFs) were modulated at different temperatures. With the increase in temperature (from 25 to 200 °C), the maximum absorption frequency of the frequency tunable aerogel is modulated from 12.24 to 8.56 GHz in the X-band, and the absorption intensity remains stable. The maximum effective switching bandwidth (ΔEAB) of the wave-absorbing switchable aerogel is 3.70 GHz. This study provides insights into intelligent electromagnetic wave absorption performance and paves the way for temperature-driven application of intelligent modulation of electromagnetic absorbers.

8.
Heliyon ; 10(10): e30909, 2024 May 30.
Artículo en Inglés | MEDLINE | ID: mdl-38778961

RESUMEN

Background: Observational studies have found a potential link between the use of thiazolidinediones (TZDs) and a lower risk of Alzheimer's disease (AD) development. Platelets were the great source of amyloid-ß (Aß) and involved in the development of AD. This study aimed to assess the correlation between antidiabetic agents and platelet characteristics, hoping to provide a potential mechanism of TZDs neuroprotection in AD. Method: Drug-targeted Mendelian randomization (MR) was performed to systematically illustrate the long-term effects of antidiabetic agents on platelet characteristics. Four antidiabetic agent targets were considered. Positive control analysis for type 2 diabetes (T2D) was conducted to validate the selection of instrumental variables (IVs). Colocalization analysis was used to further strengthen the robustness of the results. Result: Positive control analysis showed an association of four antidiabetic agents with lower risk of T2D, which was consistent with their mechanisms of action and previous evidence from clinical trials. Genetically proxied TZDs were associated with lower platelet count (ß[IRNT] = -0.410 [95 % CI -0.533 to -0.288], P = 5.32E-11) and a lower plateletcrit (ß[IRNT] = -0.344 [95 % CI -0.481 to -0.206], P = 1.04E-6). Colocalization suggested the posterior probability of hypothesis 4 (PPH4) > 0.8, which further strengthened the MR results. Conclusion: Genetically proxied TZDs were causally associated with lower platelet characteristics, particularly platelet count and plateletcrit, providing insight into the involvement of platelet-related pathways in the neuroprotection of TZDs against AD. Future studies are warranted to reveal the underlying molecular mechanism of TZDs' neuroprotective effects through platelet pathways.

9.
ACS Nano ; 18(20): 13384-13396, 2024 May 21.
Artículo en Inglés | MEDLINE | ID: mdl-38736184

RESUMEN

Silicon (Si) stands out as a promising high-capacity anode material for high-energy Li-ion batteries. However, a drastic volume change of Si during cycling leads to the electrode structure collapse and interfacial stability degradation. Herein, a multifunctional quasisolid gel polymer electrolyte (QSGPE) is designed, which is synthesized through the in situ polymerization of methylene bis(acrylamide) with silica-nanoresin composed of nanosilica and a trifunctional cross-linker in cells, leading to the creation of a "breathing" three-dimensional elastic Li-ion conducting framework that seamlessly integrates an electrode, a binder, and an electrolyte. The silicon particles within the anode are encapsulated by buffering the QSGPE after cross-linking polymerization, which synergistically interacts with the existing PAA binder to reinforce the electrode structure and stabilize the interface. In addition, the formation of the LiF- and Li3N-rich SEI layer further improves the interfacial property. The QSGPE demonstrates a wide electrochemical window until 5.5 V, good flame retardancy, high ionic conductivity (1.13 × 10-3 S cm-1), and a Li+ transference number of 0.649. The advanced QSGPE and cell design endow both nano- and submicrosized silicon (smSi) anodes with high initial Coulombic efficiencies over 88.0% and impressive cycling stability up to 600 cycles at 1 A g-1. Furthermore, the NCM811//Si cell achieves capacity retention of ca. 82% after 100 cycles at 0.5 A g-1. This work provides an effective strategy for extending the cycling life of the Si anode and constructing an integrated cell structure by in situ polymerization of the quasisolid gel polymer electrolyte.

10.
Biomed Chromatogr ; 38(7): e5885, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38736272

RESUMEN

Zhujing pill (ZP) is a famous Chinese herbal formula that has been widely used to treat diabetic retinopathy, macular degeneration, retinitis pigmentosa and other fundus lesions. In this study, the material basis and mechanism of ZP in the treatment of fundus lesions were evaluated via the high-performance liquid chromatography fingerprint, ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry, network pharmacology and molecular docking. A total of 32 common components were found and 31 components were identified in 15 batches of ZP samples. Moreover, 134 common key targets and 17 putative active components that are connected to fundus lesions were identified. Molecular docking revealed that quercetin, kaempferol, isorhamnetin, 5-O-feruloylquinic acid, plantagoside and 2'-acetylacteoside have the ability to interact with the core targets such as AKT1, TP53, TNF, IL-6 and Jun. Our findings revealed that the therapeutic effects of ZP on fundus lesions are mediated by multiple components, targets and pathways, including at least six active ingredients and 11 targets. The study provides new ideas for further research on the material basis and mechanisms of traditional Chinese medicine prescriptions.


Asunto(s)
Medicamentos Herbarios Chinos , Simulación del Acoplamiento Molecular , Farmacología en Red , Medicamentos Herbarios Chinos/química , Medicamentos Herbarios Chinos/farmacología , Cromatografía Líquida de Alta Presión/métodos , Humanos , Espectrometría de Masas/métodos
11.
Tob Induc Dis ; 222024.
Artículo en Inglés | MEDLINE | ID: mdl-38638420

RESUMEN

INTRODUCTION: Acupuncture and related acupoint therapies have been widely used for smoking cessation. Some relevant systematic reviews (SRs) have been published. There is a need to summarize and update the evidence to inform practice and decision-making. METHODS: Eight databases were searched from their inception to December 2023. SRs, any randomized controlled trials (RCTs) comparing acupuncture therapies with sham acupuncture, pharmacotherapy, behavioral therapy, or no treatment, were included. The primary outcome was the abstinence rate. AMSTAR-2 was employed to assess the quality of SRs. An updated meta-analysis was conducted based on SRs and RCTs. Data were synthesized using risk ratios (RR) with 95% confidence intervals (CIs). The GRADE approach was employed to assess the certainty of the updated evidence. RESULTS: Thirteen SRs and 20 RCTs outside of the SRs were identified. The SRs were of low or very low quality by AMSTAR-2. Sixteen (80%) RCTs were at high risk of performance bias. Eight acupuncture and related acupoint therapies were involved. The short-term (≤6 months) abstinence rate outcome was summarized as follows. Most SRs suggested that filiform needle acupuncture or acupressure had a better effect than sham acupuncture, but the findings were inconsistent. The updated meta-analysis also suggested that filiform needle acupuncture was more effective than sham acupuncture (RR=1.44; 95% CI: 1.02-2.02; I2 = 66%; low certainty; 9 RCTs, n=1358). Filiform needle acupuncture combined with acupressure was comparable to nicotine patches (RR=0.99; 95% CI: 0.74-1.32; low certainty; 6 RCTs, n= 524). Acupressure was superior to counseling (RR=1.46; 95% CI: 1.14-1.87; I2=5%; low certainty; 8 RCTs, n=595). No serious adverse events were reported in these SRs or RCTs. CONCLUSIONS: Low certainty evidence suggests that filiform needle acupuncture and auricular acupressure appear to be safe and effective in achieving short-term smoking cessation. However, long-term follow-up data are needed.

12.
Int J Dermatol ; 2024 Apr 17.
Artículo en Inglés | MEDLINE | ID: mdl-38632699

RESUMEN

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, potentially life-threatening skin disease often requiring long-term therapy. We aimed to evaluate the use of Interleukin (IL)-17A inhibitors (secukinumab and ixekizumab) in GPP patients over 96 weeks. METHODS: We retrospectively analyzed a case series of 18 patients with GPP who received secukinumab (n = 13) and ixekizumab (n = 5) therapy with a 96-week follow-up period. The primary effectiveness analysis included determining the percentage of patients who achieved ≥90% or 100% improvement in the Generalized Pustular Psoriasis Area and Severity Index (GPPASI) score. Adherence was captured using the medication possession ratio (MPR). RESULTS: Using the as-observed (AO) method, 87% and 67% of patients treated with secukinumab or ixekizumab achieved GPPASI 90 and 100 responses, respectively. At Week 96, the mean GPPASI improvements from baseline GPPASI were 96.3% (95% CI: 0.91-1.01) using the AO method. After Week 48, 14 patients tapered (n = 8) or terminated (n = 6) the treatment. High-adherence therapy (MPR ≥ 80%) was significantly superior to the low-adherence group in the rate of patients achieving a GPPASI 100 response (AO, 100% vs. 38%, P < 0.05). By Week 96, 5 (27.8%) patients had new GPP flares, and 4 (80%) were in the low-adherence group. No new safety signals occurred. CONCLUSION: IL-17A inhibitors led to effective and sustained improvement in GPP patients, and high-adherence therapy had long-term positive effects on skin clearance. Given its relapsing nature, improving compliance is beneficial for long-term clinical management.

13.
Small ; 20(35): e2400115, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38678491

RESUMEN

High-power-density electronic devices under vibrations call for soft and damping thermal interface materials (TIMs) for efficient heat dissipation. However, integrating low hardness, high damping, and superior heat transfer capability into one TIM is highly challenging. Herein, soft, damping, and thermally conductive TIMs are designed and prepared by constructing a honeycomb-board-mimetic boron nitride nanosheet (BNNS) network in a dynamic polyimine via one-step horizontal centrifugal casting. The unique filler network makes the TIMs perform a high through-plane thermal conductivity (> 7.69 W m-1 K-1) and a uniform heat transfer process. Meanwhile, the hierarchical dynamic bonding of the polyimine endows the TIMs with low compressive strength (2.16 MPa at 20% strain) and excellent damping performance (tan δ > ≈0.3 at 10-2-102 Hz). The resulting TIMs also exhibit electrical insulation and remarkable recycling ability. Compared with the commercial ones, the TIMs provide better heat dissipation (4.1 °C) for a high-power 5G base station and less temperature fluctuation (1.8 °C) for an automotive insulated gate bipolar transistor (IGBT) under vibrations. This rational design offers a viable approach to prepare soft and damping TIMs for effective heat dissipation of high-power-density electronic devices under vibrations.

14.
Small Methods ; : e2301772, 2024 Mar 21.
Artículo en Inglés | MEDLINE | ID: mdl-38513234

RESUMEN

Efficient electromagnetic waves (EMWs) absorbing materials play a vital role in the electronic era. In traditional research on microwave absorbing (MA) materials, the synergistic modulation of material dispersion and structural dispersion of EMWs by incorporating multi-scale effects has frequently been overlooked, resulting in an untapped absorption potential. In this study, the material dispersion customization method based on biomass carbon is determined by quantitative analysis. The study carries out thermodynamic modulation of carbon skeleton, micro-nano porous engineering, and phosphorus atom donor doping in turn. The dielectric properties are improved step by step. In terms of structural dispersion design, inspired by the theory of antenna reciprocity, a Vivaldi antenna-like absorber is innovatively proposed. With the effective combination of material dispersion and structural dispersion engineering by 3D printing technology, the ultra-wideband absorption of 36.8 GHz and the angular stability of close to 60 ° under dual polarization are successfully realized. The work breaks the deadlock of mutual constraints between wave impedance and attenuation rate through the dispersion modulation methods on multiple scales, unlocking the potential for designing next-generation broadband wide-angle absorbers.

15.
J Dermatolog Treat ; 35(1): 2321188, 2024 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-38531383

RESUMEN

BACKGROUND: As one of the most effective biologic treatments for psoriasis, the short-term effectiveness of ustekinumab has yet to be studied extensively. OBJECTIVE: The purpose of this study was to evaluate the short-term effectiveness and potential factors within four weeks after the first-dose ustekinumab treatment based on real-world data. METHODS: The study enrolled 98 patients with moderate-to-severe psoriasis, given ustekinumab 45 mg at week 0, week 4, and then every 12 weeks. Based on clinical data collected at baseline and week 4, we investigated the short-term effectiveness of ustekinumab after the first dose and potential factors associated with the treatment. For evaluation, we collected demographic information, body data, medical history, laboratory examination results, Psoriasis Area and Severity Index (PASI), body surface area (BSA), and dermatology life quality index (DLQI). Response rates were calculated based on the number of patients that achieved a 75/90/100% reduction in PASI (PASI 75/90/100), and the primary treatment goal was to achieve PASI 75. RESULTS: The response rates for PASI 75/90/100 at week 4 were 30.5%, 18.9%, and 16.8%, respectively. For PASI 75, the response rate was higher in patients without metabolic syndrome (MS) (without MS vs. with MS: 36.9% vs. 5.9%, p = 0.013); the serum triglyceride (TG) level was significantly lower in patients achieving PASI 75 (expressed as mean ± standard deviation, achieved vs. unachieved: 1.82 ± 1.79 vs. 3.59 ± 8.89, p = 0.010). For PASI 100, the response rates were higher in female patients (female vs. male: 26.3% vs. 10.5%, p = 0.044) and patients with a family history of psoriasis (with family history vs. without family history: 44.4% vs. 13.9%, p = 0.042). In addition, the possibility of achieving PASI 75/90/100 went up along with the serum high-density lipoprotein cholesterol (HDL-C) level (expressed as adjusted odds ratio < 95% confidence interval>: PASI 75: 28.484 < 2.035-248.419>, p = 0.011; PASI 90: 28.226 < 2.828-281.729>, p = 0.004; PASI 100: 12.175 < 1.876-79.028>, p = 0.009). CONCLUSION: In this study, nearly one-third of patients achieved PASI 75 after only the first-dose ustekinumab treatment. Sex, family history of psoriasis, MS, serum TG level might affect the short-term effectiveness, and serum HDL-C level may be a potential factor. The possibility of achieving treatment goals (PASI 75/90/100) at week 4 increased along with serum HDL-C levels.


Asunto(s)
Psoriasis , Ustekinumab , Humanos , Masculino , Femenino , Ustekinumab/uso terapéutico , Resultado del Tratamiento , Psoriasis/tratamiento farmacológico , China , Índice de Severidad de la Enfermedad
16.
Curr Top Med Chem ; 24(8): 667-685, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38549525

RESUMEN

Peptides acquire target affinity based on the combination of residues in their sequences and the conformation formed by their flexible folding, an ability that makes them very attractive biomaterials in therapeutic, diagnostic, and assay fields. With the development of computer technology, computer-aided design and screening of affinity peptides has become a more efficient and faster method. This review summarizes successful cases of computer-aided design and screening of affinity peptide ligands in recent years and lists the computer programs and online servers used in the process. In particular, the characteristics of different design and screening methods are summarized and categorized to help researchers choose between different methods. In addition, experimentally validated sequences are listed, and their applications are described, providing directions for the future development and application of computational peptide screening and design.


Asunto(s)
Simulación por Computador , Péptidos , Ligandos , Péptidos/química , Diseño de Fármacos , Diseño Asistido por Computadora , Humanos
17.
J Rheumatol ; 51(7): 678-681, 2024 Jul 01.
Artículo en Inglés | MEDLINE | ID: mdl-38490673

RESUMEN

OBJECTIVE: To determine the minimal important change (MIC) and meaningful change value (MCV) of the Disease Activity Index for Psoriatic Arthritis (DAPSA) and the effect size (ES) of DAPSA. METHODS: This was a retrospective cohort study, recruiting 106 patients who agreed to participate in the research from the Department of Dermatology, Xiangya Hospital, between November 1, 2019, and April 1, 2023. An anchor-based method using linear regression analyses was used to determine the MICs and MCVs of the DAPSA. The anchor question assessed whether the patient's well-being had changed since their previous visit, employing a 5-point Likert scale that ranged from "much improved" to "much deteriorated." RESULTS: The overall MIC value was 8.4 (95% CI 0.01-16.75). The MIC improvement was 9.5 (95% CI 0.89-18.14) and MIC deterioration was 1.1 (95% CI -9.81 to 12.05). The overall MCV was 10.5 (95% CI 4.34-16.72). MCV improvement was 11.4 (95% CI 5.95-16.95) and MCV deterioration was 1.1 (95% CI -9.81 to 12.05). The ES was 0.6. CONCLUSION: A change in DAPSA of 8.4 is indicative of an MIC, offering physicians an additional means to contextualize the patient's perception of disease activity during treatment, and a change in DAPSA of 10.5 is likely to be regarded as MCV. These values can enhance the utility of DAPSA in psoriatic arthritis clinical trials.


Asunto(s)
Artritis Psoriásica , Índice de Severidad de la Enfermedad , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Artritis Psoriásica/diagnóstico , China , Pueblos del Este de Asia , Estudios Longitudinales , Diferencia Mínima Clínicamente Importante , Estudios Retrospectivos
18.
Chem Sci ; 15(7): 2473-2479, 2024 Feb 14.
Artículo en Inglés | MEDLINE | ID: mdl-38362438

RESUMEN

Rechargeable Li-CO2 batteries are regarded as an ideal new-generation energy storage system, owing to their high energy density and extraordinary CO2 capture capability. Developing a suitable cathode to improve the electrochemical performance of Li-CO2 batteries has always been a research hotspot. Herein, Ni-Fe-δ-MnO2 nano-flower composites are designed and synthesized by in situ etching a Ni-Fe PBA precursor as the cathode for Li-CO2 batteries. Ni-Fe-δ-MnO2 nanoflowers composed of ultra-thin nanosheets possess considerable surface spaces, which can not only provide abundant catalytic active sites, but also facilitate the nucleation of discharge products and promote the CO2 reduction reaction. On the one hand, the introduction of Ni and Fe elements can improve the electrical conductivity of δ-MnO2. On the other hand, the synergistic catalytic effect between Ni, Fe elements and δ-MnO2 will greatly enhance the cycling performance and reduce the overpotential of Li-CO2 batteries. Consequently, the Li-CO2 battery based on the Ni-Fe-δ-MnO2 cathode shows a high discharge capacity of 8287 mA h g-1 and can stabilize over 100 cycles at a current density of 100 mA g-1. The work offers a promising guideline to design efficient manganese-based catalysts for Li-CO2 batteries.

19.
Water Res ; 250: 121077, 2024 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-38183800

RESUMEN

In recent decades, the environmentally benign electrochemical softening process has been gaining widespread interest as an emerging alternative for water softening. But, in spite of decades of research, the fundamental advances in laboratory involving electrolytic cell design and treatment system development have not led to urgently needed improvements in industrially practicable electrochemical softening technique. In this review, we firstly provide the critical insights into the mechanism of the currently widely used cathode precipitation process and its inherent limitations, which seriously impede its wide implementation in industry. To relieve the above limitations, some cutting-edge electrochemically homogeneous crystallization systems have been developed, the effectiveness of which are also comprehensively summarized. In addition, the pros and cons between cathode precipitation and electrochemically homogeneous crystallization systems are systematically outlined in terms of performance and economic evaluation, potential application area, and electrolytic cell and system complexity. Finally, we discourse upon practical challenges impeding the industrial-scale deployment of electrochemical water softening technique and highlight the integration of strong engineering sense with fundamental research to realize industry-scale deployment. This review will inspire the researchers and engineers to break the bottlenecks in electrochemical water softening technology and harness this technology with the broadened industrial application area.


Asunto(s)
Purificación del Agua , Ablandamiento del Agua , Ablandamiento del Agua/métodos , Purificación del Agua/métodos , Técnicas Electroquímicas/métodos , Electrólisis , Electrodos
20.
Exp Dermatol ; 33(1): e15011, 2024 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-38284208

RESUMEN

Psoriasis is an immune-mediated inflammatory disease commonly accompanied by various metabolic disorders. It is widely known that biologics could affect the metabolic status and comorbidities in psoriasis patients, however, the effects of biologics on metabolism in psoriasis patients remain poorly understood. The aim of this study was to elucidate the characteristic changes of metabolic profiling in psoriasis vulgaris (PsV) patients before and after applying biologics. Plasma samples were collected from a retrospective cohort of 43 PsV patients. Non-targeted metabolomics analyses were performed using liquid chromatography-mass spectrometry (LC-MS) to compare the metabolic profiles before and after applying adalimumab (ADA) or ixekizumab (IXE) for 4 weeks. Additionally, correlation analyses were conducted to investigate the associations between metabolite expression levels and clinical characteristics. The biologics significantly affected the metabolic profiles of PsV patients especially in glycerophospholipids (GPs). First, phosphatidylcholine (PC), unsaturated lysophosphatidylcholine (LPC), unsaturated lysophosphatidic acid (LPA) and unsaturated lysophosphatidylethanolamine (LPE) were significantly up-regulated, whereas phosphatidylethanolamine (PE), saturated LPC, saturated LPA and saturated LPE were predominantly down-regulated after biologic treatment. What is more, the changes in PE and LPA were mainly observed after applying IXE instead of ADA. Second, we also found GPs including PC, unsaturated LPC, unsaturated LPA and unsaturated LPE were primarily negatively correlated with disease severity, whereas, PE, saturated LPC, saturated LPA and saturated LPE displayed inverse correlations. Biologics could affect GP metabolism and facilitate the transition of metabolic status from a pro-inflammatory to an anti-inflammatory phenotype in PsV patients.


Asunto(s)
Productos Biológicos , Psoriasis , Humanos , Estudios Retrospectivos , Psoriasis/tratamiento farmacológico , Adalimumab/uso terapéutico , Fosfatidilcolinas , Productos Biológicos/uso terapéutico
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