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1.
Curr Drug Metab ; 18(2): 145-156, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-28093997

RESUMEN

Sonication-assisted nanoprecipitation provides an effective tool for nanomedicine engineering in therapeutic improvement. In the scope of this review, original works in interdisciplinary areas of using sonication with precipitation method for nanoparticulate drug delivery systems and its applications in management of different diseases are discussed. The use of sonication-assisted nanoprecipitation has been proved to improve drug bioavailability, which attracts tremendous interests as an effective strategy for drug delivery. However, many challenges still remain. To overcome these barriers, different approaches such as precipitation method, rational design, optimization and modification have been investigated. Accordingly, current knowledge of sonication-assisted nanoprecipitation proposes a broad perspective and optimization for the applications of nanotechnology in drug delivery.


Asunto(s)
Nanopartículas/química , Precipitación Química , Sistemas de Liberación de Medicamentos , Liberación de Fármacos , Nanopartículas/administración & dosificación , Nanopartículas/uso terapéutico , Nanotecnología , Sonicación
2.
Mater Sci Eng C Mater Biol Appl ; 67: 1-7, 2016 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-27287092

RESUMEN

The aim of this study was to investigate the effect of modification processes on physical properties and explain the mechanism of sustained drug release from modified rice (MR). Various types of Vietnamese rice were introduced in the study as the matrices of sustained release dosage form. Rice was thermally modified in water for a determined temperature at different times with a simple process. Then tablets containing MR and isradipine, the model drug, were prepared to investigate the capability of sustained drug release. Scanning electron microscopy (SEM) was used to determine different morphologies between MR formulations. Flow property of MR was analyzed by Hausner ratio and Carr's indices. The dissolution rate and swelling/erosion behaviors of tablets were evaluated at pH 1.2 and pH6.8 at 37±0.5°C. The matrix tablet containing MR showed a sustained release as compared to the control. The SEM analyses and swelling/erosion studies indicated that the morphology as well as swelling/erosion rate of MR were modulated by modification time, drying method and incubation. It was found that the modification process was crucial because it could highly affect the granule morphologies and hence, leading to the change of flowability and swelling/erosion capacity for sustained release of drug.


Asunto(s)
Oryza/química , Preparaciones de Acción Retardada/química , Preparaciones de Acción Retardada/farmacocinética
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