Impact of Primary Percutaneous Coronary Intervention on Complete Atrioventricular Block With Acute Inferior ST-Elevation Myocardial Infarction.

Background and aims Complete atrioventricular block (CAVB) is associated with poor clinical outcomes in ST-elevation myocardial infarction (STEMI). This study determined the frequency and outcomes of primary percutaneous coronary intervention (PPCI) in patients with CAVB with acute inferior STEMI. Methods We conducted an observational, prospective study and enrolled 151 patients who were diagnosed with inferior STEMI. All patients received PPCI. The clinical outcomes were compared in patients with and without CAVB. The data was recorded on a collection form and analyzed on Statistical Package for Social Sciences (SPSS) software. Descriptive statistics were applied. For quantitative variables, standard deviation and mean were obtained, and statistical tests were also applied. Results Baseline characteristics were homogeneous in all patients. Half of the study population was either diabetic or hypertensive. Out of 151 participants, 21 (13.9%) developed CAVB. Two-thirds of the patients, who had developed heart block, reverted after PPCI. After a follow-up of two weeks, in-hospital mortality did not differ between the groups. Conclusion We conclude that PPCI can improve outcomes of CAVB-complicated acute inferior STEMI and suggest that primary PCI should be the preferred reperfusion therapy in patients with CAVB with STEMI.

Newborn Vitamin K Prophylaxis: A Historical Perspective to Understand Modern Barriers to Uptake.

Since its initial discovery almost a century ago, vitamin K has been labeled as both lifesaving and malignancy causing. This has led to debate of not only its use in general but also regarding its appropriate dose and route. In this article, we review through a historical lens the past 90 years of newborn vitamin K from its discovery through to its modern use of preventing vitamin K deficiency bleeding (VKDB). Although researchers in surveillance studies have shown considerable reductions in VKDB following intramuscular vitamin K prophylaxis, ongoing barriers to the universal uptake of vitamin K prophylaxis remain. Reviewing the history of newborn vitamin K provides an opportunity for a greater understanding of the current barriers to uptake that we face. Although at times difficult, improving this understanding may allow us to address contentious issues related to parental and health professional beliefs and values as well as improve overall communication. The ultimate goal is to improve and maintain the uptake of vitamin K to prevent VKDB in newborns.

To determine the probable causes of death in an urban slum community of Pakistan among adults 18 years and above by verbal autopsy.

OBJECTIVE: To identify the probable causes of deaths through verbal autopsy and identify the health problems prevalent in underprivileged and marginalized communities. METHODS: This was a cross-sectional survey conducted at the community of Nurpur Shahan (Urban Slum), Islamabad, Pakistan in January 2010. W.H.O validated questionnaire was used and 300 adults (age > 18 years) were assessed on their knowledge regarding death of their relatives. All data collected was entered into SPSS version 10.0. The data was re-validated and analyzed. RESULTS: Out of the three hundred deaths, 191(63.7%) were male and 109(36%) were female. One hundred and ninety one (63.7%) deaths were due to heart diseases, 69 (23%) due to accidents and 37 (12.3%) due to unknown causes. One hundred and thirty one of the deceased (43.7%) were issued death certificates. CONCLUSION: This study concludes that heart diseases are the most common cause of death in the urban slum community followed by accidents. A significant proportion of the deaths went unreported which suggests the need of record keeping of such deaths to enrich epidemiological purposes and health and safety interventions in such communities. Ways and means have to be searched to cater to the cardiac health care needs of the underprivileged and marginalized segments of the society.