RESUMEN
Sodium nucleinate increased essentially the insusceptibility of mice to pathogenic escherichia, strain O26, Pr. vulgaris, Ps. aeruginosa, Ser. marcescens, and produced a total stimulating effect on the nonspecific bacterial resistance; analogous stimulating activity was found in the homologous low polymeric RNA from the liver. Sodium nucleinate intensified the insusceptibility of the animals to the tick-born encephalitis and encephalomyelitis viruses, and increased the antibody-forming cells count. The side-effect of heat-inactivated vaccine from pathogenic escherichia was reduced in animals inoculated with sodium nucleinate preliminarily.
Asunto(s)
Anticuerpos Antibacterianos/biosíntesis , Anticuerpos Antivirales/biosíntesis , Inmunidad Innata/efectos de los fármacos , ARN/inmunología , Animales , Células Productoras de Anticuerpos/inmunología , Relación Dosis-Respuesta Inmunológica , Virus de la Encefalitis Equina del Oeste/patogenicidad , Virus de la Encefalitis Transmitidos por Garrapatas/patogenicidad , Escherichia coli/patogenicidad , Inmunización , Ratones , Ratones Endogámicos CBA , Ácidos Nucleicos/inmunología , Proteus vulgaris/patogenicidad , Pseudomonas aeruginosa/patogenicidad , Serratia marcescens/patogenicidad , Factores de TiempoRESUMEN
The investigation of antiviral antibody titers to 8 different antigens: measles, influenza A2 and B, parainfluenza types 1, 2, 3, adenovirus and smallpox, of interferon in the blood serum, the interferon-synthesizing activity of the peripheral blood leukocytes in patients with autoimmune diseases in the period of the disease exacerbation revealed a number of immunological features. Thus, in all groups of patients antibody titers were high to measles, influenza, parainfluenza type 3 viruses, and titers of leukocyte interferon and interferon in the blood serum were 3-4-fold lower than in the control group.