Metabolic tumour volume is prognostic in patients with non-small-cell lung cancer treated with stereotactic ablative radiotherapy.

Introduction: Stereotactic ablative radiotherapy (sabr) is a relatively new technique for the curative-intent treatment of patients with inoperable early-stage non-small-cell lung cancer (nsclc). Previous studies have demonstrated a prognostic value for positron emission tomography-computed tomography (pet/ct) parameters, including maximal standardized uptake value (suvmax), metabolic tumour volume (mtv), and total lesion glycolysis (tlg) in lung cancer patients. We aimed to determine which pet/ct parameter is most prognostic of local control (lc) and overall survival (os) in patients treated with sabr for nsclc. Methods: We conducted a retrospective review of patients treated with sabr for stage I inoperable nsclc at BC Cancer between 2009 and 2013. The Akaike information criterion was used to compare the prognostic value of the various pet/ct parameters. Results: The study included 134 patients with a median age of 76 years. Median tumour diameter was 2.2 cm, gross tumour volume was 8.1 mL, suvmax was 7.9, mtv was 2.4 mL, and tlg was 10.9 suv·mL. The 2-year lc was 92%, and os was 66%. On univariate and multivariate analysis, imaging variables including tumour size, gross tumour volume, suvmax, mtv, and tlg were all associated with worse lc. Tumour size was not associated with significantly worse os, but other imaging variables were. The pet/ct parameter most prognostic of lc was mtv. Compared with suvmax, tlg and mtv were more prognostic of os. Conclusions: In patients with early-stage nsclc treated with sabr, mtv appears to be prognostic of lc and os.

Surface Roughness Studies with DALLAS-Detector Array for Laser Light Angular Scattering.

An instrument has been developed to study surface roughness by measuring the angular distributions of scattered light. In our instrument, a beam from a He-Ne laser illuminates the surface at an angle of incidence which may be varied. The scattered light distribution is detected by an array of 87 fiber optic sensors positioned in a semicircular yoke which can be rotated about its axis so that the scattered radiation may be sampled over an entire hemisphere. The output from the detector array is digitized, stored, and analyzed in a laboratory computer. The initial experiments have concentrated on measurements of stainless steel surfaces which are highly two-dimensional and which yield scattering distributions that are localized in the plane of incidence. The results are analyzed by comparing the angular scattering data with theoretical angular scattering distributions computed from digitized roughness profiles measured by a stylus instrument. The theoretical distributions are calculated by substituting the roughness profiles into the operand of an integral equation for electromagnetic scattering developed by Beckmann and Spizzichino. This approach directly tests the accuracy of the basic optical theory.