RESUMEN
BACKGROUND: The relative effects of levetiracetam (LEV) and carbamazepine (CBZ) on cognitive and neurophysiologic measures are uncertain. METHODS: The effects of LEV and CBZ were compared in healthy adults using a randomized, double-blind, two-period crossover design. Outcome measures included 11 standard neuropsychological tests and the score from a cognitive-neurophysiologic test of attention and memory. Evaluations were conducted at screening, baseline pre-drug treatment, end of each maintenance phase (4 weeks), and end of each washout period after drug treatment. RESULTS: A total of 28 adults (17 women) with mean age of 33 years (range 18 to 51) completed the study. Mean maintenance doses (+/-SD) were CBZ = 564 mg/day (110) and LEV = 2,000 mg/day (0). CBZ was adjusted to mid-range therapeutic level. Mean serum levels (+/-SD) were CBZ = 7.5 mcg/mL (1.5) and LEV = 32.2 mcg/mL (11.2). An overall composite score including all measures revealed worse effects for CBZ compared to LEV (p Asunto(s)
Carbamazepina/farmacología
, Pruebas Neuropsicológicas
, Piracetam/análogos & derivados
, Desempeño Psicomotor/efectos de los fármacos
, Desempeño Psicomotor/fisiología
, Adolescente
, Adulto
, Estudios Cruzados
, Método Doble Ciego
, Electroencefalografía/efectos de los fármacos
, Femenino
, Humanos
, Levetiracetam
, Masculino
, Persona de Mediana Edad
, Piracetam/farmacología
, Sensibilidad y Especificidad