RESUMEN
Mammary analog secretory carcinoma (MASC) of the parotid gland is a rare and recently described lesion. We report the case of a 46-year-old man with a tumor of the parotid gland which was carried to the diagnosis of MASC. Diagnostic was confirmed by highlighting the ETV6-NTRK3 gene translocation. However, some morphologic and immunohistochemical features are suggestive of this entity. This carcinoma should be distinguished from its main differential diagnoses: acinic cell carcinoma and low grade cribriform cystadenocarcinoma.
Asunto(s)
Carcinoma/patología , Neoplasias de la Parótida/patología , Biomarcadores de Tumor/análisis , Carcinoma/química , Carcinoma/genética , Carcinoma de Células Acinares , Cistadenocarcinoma , Diagnóstico Diferencial , Humanos , Inmunohistoquímica , Masculino , Persona de Mediana Edad , Proteínas de Fusión Oncogénica/genética , Neoplasias de la Parótida/química , Neoplasias de la Parótida/genética , Translocación GenéticaAsunto(s)
Antineoplásicos/efectos adversos , Indoles/efectos adversos , Neoplasias Renales/patología , Pirroles/efectos adversos , Glándula Tiroides/diagnóstico por imagen , Tirotoxicosis/inducido químicamente , Tirotoxicosis/patología , Adulto , Antineoplásicos/uso terapéutico , Femenino , Bocio/etiología , Bocio/patología , Humanos , Indoles/uso terapéutico , Neoplasias Renales/tratamiento farmacológico , Pirroles/uso terapéutico , Sunitinib , Pruebas de Función de la Tiroides , Tomografía Computarizada por Rayos XRESUMEN
OBJECTIVES/HYPOTHESIS: Advanced carcinoma of the tongue can require total glossectomy. Although radiation therapy is of limited efficacy in T3 and T4 tumors involving the base of the tongue, many surgeons are reluctant to suggest highly mutilating surgery. STUDY DESIGN: Retrospective cohort study. METHODS: We compared early postoperative complications, hospital stay duration, function, and oncological outcomes in patients who underwent total glossectomy without laryngectomy as first-line or salvage therapy. RESULTS: Postoperative course and functional outcomes were similar in the two groups. Overall survival was 32% at 3 years and 21% at 5 years. The risk factors for shorter survival were positive margins of resection (P =.002) and tumor spread into the mandible (P =.04). Salvage surgery was not associated with significantly lower survival (P =.09 [NS]). CONCLUSIONS: Postoperative morbidity and functional outcomes are similar after first-line and salvage total glossectomy without laryngectomy. Local tumor control is the main factor influencing survival.