RESUMEN
The article presents data of Cancer Registry in Novosibirsk for the period 1988-2012 concerning primary liver cancer. Over the period studied the incidence and mortality have declined significantly (2,5 and 2,1 times, respectively). Both figures fall in line for men and women being generally twice as high in men. The long-term trends of main etiologic risk factor for liver cancer (prevalence of hepatitis viruses B and C in the population) are shown. The issues of screening and prevention are discussed.
Asunto(s)
Hepacivirus , Virus de la Hepatitis B , Hepatitis B/epidemiología , Hepatitis C/epidemiología , Neoplasias Hepáticas , Sistema de Registros , Humanos , Incidencia , Neoplasias Hepáticas/epidemiología , Neoplasias Hepáticas/virología , Estudios Retrospectivos , Siberia/epidemiologíaRESUMEN
Dynamics of morbidity and mortality from pancreatic cancer in the population of Novosibirsk according to the Population-based Cancer Registry and the Registry of total mortality for 25 years (1988-2012) were analyzed. The morbidity and mortality for the studied period decreased slightly. Incidence rates in middle-aged males are higher than in females but this difference is leveled after 75 years. Possible risk factors for pancreatic cancer as well as issues of screening and prevention are discussed.
Asunto(s)
Diabetes Mellitus/mortalidad , Infecciones/mortalidad , Neoplasias Pancreáticas/mortalidad , Pancreatitis Crónica/mortalidad , Adulto , Factores de Edad , Anciano , Consumo de Bebidas Alcohólicas/epidemiología , Diabetes Mellitus/patología , Femenino , Humanos , Incidencia , Infecciones/complicaciones , Infecciones/patología , Masculino , Persona de Mediana Edad , Morbilidad , Neoplasias Pancreáticas/complicaciones , Neoplasias Pancreáticas/patología , Pancreatitis Crónica/complicaciones , Sistema de Registros , Factores de Riesgo , Federación de Rusia/epidemiología , Caracteres Sexuales , Fumar/epidemiologíaAsunto(s)
Neoplasias Gástricas/epidemiología , Neoplasias Gástricas/prevención & control , Adulto , Distribución por Edad , Anciano , Femenino , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Morbilidad/tendencias , Mortalidad/tendencias , Prevalencia , Federación de Rusia/epidemiología , Distribución por Sexo , Neoplasias Gástricas/mortalidadRESUMEN
In a prospective study the risk of subsequent gastric cancer (GC) was assessed in persons aged 45-69 over 5 years after the initial testing with a set of serological tests (pepsinogen I, pepsinogen II, gastrin-17, antibodies to Helicobacter pylori). The presence of gastric atrophy markers was a significant predictor of GC in the forthcoming years. Non-invasive techniques may be used in the formation of high-risk groups, followed by GC active surveillance.
Asunto(s)
Anticuerpos Antibacterianos/sangre , Gastrinas/sangre , Gastritis Atrófica/sangre , Helicobacter pylori/inmunología , Pepsinógenos/sangre , Neoplasias Gástricas/sangre , Anciano , Biomarcadores/sangre , Estudios de Cohortes , Femenino , Gastritis Atrófica/enzimología , Gastritis Atrófica/inmunología , Gastritis Atrófica/microbiología , Infecciones por Helicobacter/sangre , Infecciones por Helicobacter/complicaciones , Humanos , Masculino , Persona de Mediana Edad , Pepsinógeno A/sangre , Pepsinógeno C/sangre , Estudios Retrospectivos , Pruebas Serológicas , Neoplasias Gástricas/enzimología , Neoplasias Gástricas/inmunología , Neoplasias Gástricas/microbiologíaRESUMEN
Polymorphisms of promotor region of IL-8, IL-10, and IL-12 genes were analyzed in cancer patients and subjects without history of cancer. The distribution of alleles of the analyzed polymorphisms in the control group coincided with that in other Caucasian populations. The incidences of three IL-10 gene polymorphisms (G-1082A, C-819T, and C-592A) significantly differed in controls and patients. Of 8 theoretically probable IL-10 gene haplotypes determined by these polymorphisms, 3 variants were revealed. Haplotype ACC was more incident in cancer patients, while ATA haplotype was rarer. The results are in line with the findings of other studies indicating the involvement of the immune system genes in the pathogenesis of cancer.